Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| Ftase --- FPTase | 2-(2,5-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 2-((2-(4-chlorophenyl)-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-propoxy-benzyl}-butyric acid | Drug Info |
| Ftase --- FPTase | Sodium salt of 2-Phosphonooxymethyl-N-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| NET --- SERT | CHEMBL353255 | Drug Info |
| PR --- mRNA of AR | 5-Methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((2-oxo-1-phenethylpyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| NET --- SERT | 2-(4-Chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine | Drug Info |
| PR --- mRNA of AR | 15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-isopropyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| NET --- SERT | 3-(4-Chloro-phenyl)-2-[3-(4-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-8-methyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-p-tolylpropan-1-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-5H-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinomethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| PR --- mRNA of AR | 1-Ethyl-6,8,8-trimethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-5-(3,4-dimethoxyphenyl)nicotinonitrile | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyanophenyl)-1-ethyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-difluoro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | (1E,4Z,6E)-7-(4-(Hexadecyloxy)-3-methoxyphenyl)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one | Drug Info |
| PR --- mRNA of AR | 9-chloro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclohexyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)-2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| PR --- mRNA of AR | (+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol | Drug Info |
| FTase --- GTase | 5-[(3'-Chloro-5-cyano-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile | Drug Info |
| CCKBR --- CCKAR | N-[5-(2-Fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-4-trifluoromethyl-benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((dimethylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(5-methoxymethyl-1-methyl-2-oxo-pyrrolidin-3-yl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| H3 --- SERT | 4-(3-chlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-((5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)furan-2-yl)methylamino)acetonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-methyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| Renin --- Cathepsin D | (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imidazol-4-yl)-2-[2-(naphthalen-1-yloxy)-acetylamino]-propionylamino}-2-isopropyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2,3-dimethyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,6-bis-trifluoromethyl-phenyl)-amide | Drug Info |
| H3 --- SERT | 1-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperidine-4-carbonitrile | Drug Info |
| EGFR3 --- HER2 | 4-Pyrrolidin-1-yl-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(6-(1-(2-hydroxy-3-methoxypropyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-tert-butyl-phenyl)-cycloheptyl]-amide | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)-3-(4-(trifluoromethyl)phenoxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(3-(4-((isopropylamino)methyl)phenoxy)prop-1-ynyl)-6-methylpyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957850 | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-N-phenyl-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| HD6 --- HDAC4 | 1-(5-(3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)-2,2,2-trifluoroethanone | Drug Info |
| EGFR3 --- HER2 | [5-(4-amino-piperidin-1-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-[3-chloro-4-(1-oxy-pyridin-2-ylmethoxy)-phenyl]-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R,4R)-4-hydroxy-2-(4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| S5AR --- SRD5A2 | 4-{3-[2,2-Bis-(4-chloro-phenyl)-benzo[1,3]dioxole-5-carbonyl]-2-methyl-indol-1-yl}-butyric acid | Drug Info |
| HDAC1 --- HD6 | (S)-2-(4-(dimethylamino)benzamido)-N8-hydroxy-N1-(quinolin-8-yl)octanediamide | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.