Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | (R)-2-{4-[2-(4-Cyclohexyl-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-3-phenyl-propionic acid | Drug Info |
| VEGFR2 --- CDK1 | 2-(3-methoxy-4-(pyrrolidin-1-ylmethyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | Biphenyl-2-yl-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| MMP2 --- MMP9 | 2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-morpholinoethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Hydroxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | epicatechin-(4beta-8)-epicatechin-(4beta-6)-epicatechin | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d] isoxazol-4-yl)phenyl)-3-(4-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-methoxy-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | (R)-3-(4-Phenethyl-benzenesulfonyl)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(thiophen-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | [(S)-4-[2-(3H-Imidazol-4-yl)-ethyl]-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| MMP3 --- MMP8 | 2-(5-Isoxazol-3-yl-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 7-(6,7-dimethoxyquinolin-4-yloxy)-N-isopropyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(2,3-Dihydroxy-benzoyl)-6-hydroxy-benzene-1,4-dicarbaldehyde | Drug Info |
| MMP3 --- MMP8 | 2-(4-Butoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 6-(7-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)-N-(2-methoxyethyl)nicotinamide | Drug Info |
| Ftase --- FPTase | 2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(2-pyridin-4-yl-acetyl)-piperazin-2-yl]-N-cyclopropyl-acetamide | Drug Info |
| MMP9 --- MMP3 | 2-(1-Hydroxy-2-mercapto-ethyl)-nonanoic acid [(S)-1-(2-ethylamino-4-methyl-pentanoylcarbamoyl)-5-(toluene-4-sulfonylamino)-pentyl]-amide | Drug Info |
| VEGFR2 --- CSrc | isobutyl4-(7-amino-3-(4-(4-(2-methoxyethyl)piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamate | Drug Info |
| Ftase --- FPTase | (R)-2-({4-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-biphenyl-2-carbonyl}-amino)-3-methylsulfanyl-propionic acid | Drug Info |
| mTOR --- AKT | 1-{(2R,3R)-3-[6-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonyl)pyrazin-2-ylamino]-2-phenylpyrrolidin-1-yl}ethanone | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-6-methylphenyl)-1-(6-(4-(morpholinomethyl)pyridin-2-ylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| Ftase --- FPTase | N-Cyclopentyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(3-morpholinopropyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-chlorobenzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbothioyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 3-(9-((1-benzylpiperidin-4-yl)methyl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- EGFR3 | 4-(3-bromophenoxy)-6,7-dimethoxyquinazoline | Drug Info |
| Ftase --- FPTase | N-(3-chloro-phenyl)-5-cyano-2-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-{4-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]phenyl}-urea | Drug Info |
| VEGFR2 --- FGFR1 | N-(4-Benzyloxy-butyl)-N-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-acetamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-3-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- MCSF | GW856804X | Drug Info |
| Ftase --- FPTase | 6-[(4'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | N-[2-(Dimethylamino)ethyl]-4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}aminobenzamide | Drug Info |
| VEGFR2 --- TEK | 7-amino-19-methyl-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-(2-cyano-ethyl)-N-cyclopropyl-acetamide | Drug Info |
| NET --- SERT | 3N-{7-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarboxamido]heptyl}-4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxamide | Drug Info |
| VEGFR2 --- TEK | 2-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenoxy]-benzoic acid | Drug Info |
| Ftase --- FPTase | 4-{5-[(2-Oxo-3-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| NET --- SERT | 4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid {5-[3-(4-chloro-phenyl)-acryloylamino]-pentyl}-amide | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(5-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)-2-pyridyloxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | [1-(3-Benzyl-3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1-ylmethyl)furan-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(4-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3',5'-difluoro-biphenyl-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(5-((dimethylamino)methyl)thiophen-3-yl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide | Drug Info |
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