Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-morpholinopropyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzoylamino-benzenesulfonylamino)-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-pyridin-3-yl-propan-1-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)cyclopentanecarboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenylethynyl-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[Butyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2''-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| FGFR --- VEGFR | N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| MMP2 --- MMP9 | 3-Benzyl-4-oxo-4-((4-phenylethynyl)phenyl)butyric acid | Drug Info |
| Ftase --- FPTase | 3'-chloro-6-[(4-cyano-3-fluoro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-biphenyl-3-carbonitrile | Drug Info |
| Src --- VEGFR | N-(5-chloro-1,3-benzodioxol-4-yl)-5-morpholin-4-yl-7-(2-pyrrolidin-1-ylethoxy)quinazolin-4-amine | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-4-(pyridin-4-yloxy)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | {2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-2(1H)-one | Drug Info |
| MMP2 --- MMP9 | (R)-2-Biphenyl-4-ylmethyl-N*4*-hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-succinamide | Drug Info |
| Ftase --- FPTase | 1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-pyrrol-1-yl-ethanone | Drug Info |
| VEGFR2 --- Beta PDGFR | 9-Chloro-2-({5-[3-(dimethylamino)propyl]-2-isopropylphenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]-benzazepine-6-thione | Drug Info |
| MMP2 --- MMP9 | 4-Benzylsulfanyl-2-[[(cyclohexylmethyl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-butyramide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butylamide | Drug Info |
| VEGFR2 --- CDK1 | N-(3-chlorophenyl)-6-(5-{[3-(piperidin-1-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-trimethylsilanyl-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| Ftase --- FPTase | (3aR,6R)-6-(2-Carboxy-ethyl)-3-(1,5-dimethyl-hexyl)-3a,6-dimethyl-2,3,3a,4,5,5a,6,9,9a,9b-decahydro-1H-cyclopenta[a]naphthalene-7-carboxylic acid | Drug Info |
| VEGFR2 --- CDK1 | 3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridine | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-(6-methoxy-1,1-dioxo-3,4-dihydro-1H-1lambda*6*-benzo[1,2,4]thiadiazin-2-yl)-propionamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-(3-iodo-propyl)-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| VEGFR2 --- Ckit | N-Cyclopropyl-4-methyl-3-(1-((2-(4-morpholino)ethyl)amino)-6-phthalazinyl)benzamide | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(p-tolylthio)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1H-quinolin-2-one | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(4-(dimethylcarbamoyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-pyridin-3-yl-propan-1-one | Drug Info |
| VEGFR2 --- Cmet | (R)-N1-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2,6-dichlorobenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | [3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| VEGFR2 --- Cmet | 5-amino-N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Chloro-biphenyl-4-sulfonyl)-6-nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| VEGFR2 --- CSrc | 2-((3,5-dimethoxy)-4-((2-(4-morpholinyl)ethyl)oxy)phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| MMP3 --- MMP8 | 2-[3-(2-Hydroxy-benzoylamino)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-(4-{2-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-4-methylsulfanyl-butan-1-one | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-5-isopropoxy-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| MMP3 --- MMP8 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl-biphenyl-4-sulfonylamino)-propyl]-phosphonic acid | Drug Info |
| Ftase --- FPTase | 4-[(5-chloro-3'-methoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| VEGFR2 --- CSrc | 4-methyl-3-(1-(6-(2-(4-methylpiperazin-1-yl)ethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-{(S)-1-((S)-1-phenyl-ethylcarbamoyl)-2-[4-(3-phenyl-ureido)-phenyl]-ethyl}-oxalamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-isopropyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| VEGFR2 --- CSrc | 4-methyl-3-(1-(4-(3-(4-methylpiperazin-1-yl)propylamino)-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| mTOR --- AKT | N-(5-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| VEGFR2 --- FGFR1 | N-[2-(3-tert-Butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-N-(5-hydroxy-pentyl)-acetamide | Drug Info |
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