Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | (R)-2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | 5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)-2-(methylsulfonyl)benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-chloro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| MMP2 --- MMP9 | (R)-N-hydroxy-3-(quinolin-8-ylsulfonyl)thiazolidine-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphenyl-3-carboxylic acid 37 (FTI-2317) | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N,N-dimethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[5-(4-nitro-phenylethynyl)-thiophene-2-sulfonylamino]-propionic acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Amino-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-2-naphthamide | Drug Info |
| MMP2 --- MMP9 | N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperidin-1-ylsulfonyl)methyl)tetrahydro-2H-pyran-4-yl)-N-hydroxyformamide | Drug Info |
| Ftase --- FPTase | Acetic acid 2-acetoxy-6-(3-acetoxy-2,5-diformyl-benzoyl)-phenyl ester | Drug Info |
| Lck --- VEGFR | 4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| MMP2 --- MMP9 | (S)-2-(cis-2,6-dimethylmorpholino)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-chloro-3-fluoro-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Src --- VEGFR | (6-Chloro-benzofuran-7-yl)-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-iodo-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)quinolin-2(1H)-one | Drug Info |
| MMP3 --- MMP8 | Oxo-[2-((E)-2-phenyl-ethenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Chloro-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- Beta PDGFR | 9-Chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione | Drug Info |
| MMP3 --- MMP8 | 7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| VEGFR2 --- CDK1 | N-((2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methyl)propan-2-amine | Drug Info |
| MMP3 --- MMP8 | 2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-4-yl)pyrimidin-2-amine | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-butyl]-oxalamide | Drug Info |
| Ftase --- FPTase | (S)-2-((2R)-1-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanoyl)-octahydro-1H-indole-2-carboxamido)-4-(methylthio)butanoic acid | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(3-methoxyphenyl)urea | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(2-chlorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 4-((1-(3-phenoxybenzyl)-1H-imidazol-5-yl)methyl)-1-(4-(trifluoromethyl)phenyl)piperazin-2-one | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(methylthio)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| VEGFR2 --- Cmet | N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[4-(Adamantan-1-yl-hydroxy-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide | Drug Info |
| mTOR --- PI3K gamma | SID137275852 | Drug Info |
| Ftase --- FPTase | 1-[5-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| VEGFR2 --- CSrc | 3-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-1-cyclohexyl-1-methylurea | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoate | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (1-hydroxy-pyridin-3-ylmethyl)-amide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-tert-butylphenyl)-4-methylbenzamide | Drug Info |
| NET --- SERT | SID533837 | Drug Info |
| Ftase --- FPTase | N-Benzyl-N-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-methanesulfonamide | Drug Info |
| VEGFR2 --- CSrc | 3-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-1-cyclohexyl-1-methylurea | Drug Info |
| NET --- SERT | 3-(4-Chloro-phenyl)-2-[3-(4-chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-8-methyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-2,3-dihydro-1H-indole-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
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