Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| ABL --- Src | (6,7-Dimethoxy-quinazolin-4-yl)-(4-ethoxy-3,5-dimethoxy-phenyl)-amine | Drug Info |
| Erbeta --- ER | 4-[6-(Methyl-phenethyl-amino)-4-o-tolyl-pyridin-2-yl]-phenol | Drug Info |
| MMP13 --- MMP8 | 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol | Drug Info |
| Lck --- Src | 5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Erbeta --- ER | 4-(4-Hydroxyphenyl)-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[b]oxepin-8-ol | Drug Info |
| MMP2 --- HER2 | (6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino[1,2-a]indol-2(1H)-ylcarbonyl)-5-azaspiro[2.5]octane-7-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 9-methyl-2-(trifluoromethyl)-9H-carbazole | Drug Info |
| Erbeta --- ER | 4-(5-hydroxybenzo[d]isoxazol-3-yl)benzene-1,3-diol | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-(2-amino-3-(tritylthio)propanamido)acetic acid | Drug Info |
| Erbeta --- Mcl1 | 3,5,7-trihydroxy-2-(2-hydroxyphenyl)-4H-chromen-4-one | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(4-Benzyloxy-5-ethyl-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-N,N-dimethylbutan-1-amine | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | (R)-2-(N-(2-(dimethylamino)ethyl)naphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-dimethylamino-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-{1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-cyclohexyl}-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-(2,5-difluorophenyl)-5-(thiophen-2-yl)-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid | Drug Info |
| MMP2 --- MMP13 | tert-butyl 4-(hydroxycarbamoyl)-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-1-carboxylate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-N-(3-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-oxopropyl)methanesulfonamide | Drug Info |
| Ftase --- FPTase | 1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-3-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanethione | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-dimethylamino-benzyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(pyrrolidin-1-ylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,3-dimethyl-butyl)-benzonitrile | Drug Info |
| MMP2 --- MMP3 | 4-Benzyloxy-N-hydroxy-3-(4-methoxy-benzenesulfonyl)-butyramide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-cyclopropyl-1-((S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2-hydroxyethanone | Drug Info |
| Ftase --- FPTase | 2-(3-Benzyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-phenethyl-phenyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-2-fluorophenol | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP3 | {(S)-2-[(S)-2-Cyclohexyl-1-(2-morpholin-4-yl-ethylcarbamoyl)-ethylcarbamoyl]-5-phenyl-pentyl}-phosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-2-(p-aminobenzoyl)-6-methyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-5-Benzyl-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-3,3-dimethyl-1-oxo-1-(pyridin-4-ylamino)butan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-acetoxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethylester | Drug Info |
| Ftase --- FPTase | (S)-3-Hydroxy-2-((S)-4-methyl-2-{(S)-3-methyl-2-[(E)-7,11,15-trimethyl-4-(phosphonomethyl-carbamoyl)-hexadeca-6,10,14-trienoylamino]-butyrylamino}-pentanoylamino)-propionic acid | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-[4-(2-trifluoromethyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-amine | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-3-Methyl-2-(2-phenylmethanesulfinyl-acetylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | {5-[7-(3,5-Dimethoxy-benzyloxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-5-hydroxycarbamoyl-pentyl}-carbamic acid tert-butyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(1-methylpiperidin-3-yl)methanone | Drug Info |
| Ftase --- FPTase | (S)-4-((5-(((1-benzyl-2-oxopyrrolidin-3-yl)(pyridin-3-ylmethyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | 1-((4-(4-chlorophenoxy)phenylsulfonyl)methyl)-3-hydroxypyridin-2(1H)-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-5-bromo-6-chloro-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
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