Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-6-chloro-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| EGFR3 --- HER2 | DDD01067522 | Drug Info |
| PKCA --- NPKC delta | (E)-{2-(hydroxymethyl)-4-[4-methyl-3-(methylethyl)pentylidene]-5-oxo-2,3-dihydrofur-2-yl}methyl 4-hydroxybenzoate | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(2-(4-(2-(dimethylamino)ethoxy)phenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | Drug Info |
| EGFR3 --- HER2 | (4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine | Drug Info |
| PKCA --- NPKC delta | dihexan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(4-((perfluorobenzyloxyimino)methyl)phenyl)acrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-fluoro-4'-(methylsulfonyl)-4-(trifluoromethyl)biphenyl | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-phenethyloxy-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-biphenyloxypropoxy)phenylthio)hexanoic acid | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-8-((1H-indol-3-yl)methyl)-11-isobutyl-2-methyl-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | tert-butyl 3-(N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methylbenzamido)propylcarbamate | Drug Info |
| EGFR3 --- HER2 | 4-[(2-Hydroxy-ethyl)-methyl-amino]-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E)-3-(Furan-2-yl)acryloyl]-7-(2-{5-methyl-2-[(1E)-5-methylhexen-1-yl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| HDAC1 --- HD6 | 6-((2S,5S,8S,11S)-2-(5-acetamidopentyl)-11-isobutyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (3aS,10R)-2-(5-amino-pentyl)-10-(3-hydroxy-phenyl)-3a,4,9,10-tetrahydro-2,9,10a-triaza-cyclopenta[b]fluorene-1,3-dione | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methanesulfonate | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(7-chloro-8-methyl-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-2-oxo-octanoic acid methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-8-chloro-3-(3-dimethylamino-propyl)-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| EGFR3 --- VEGFR1 | 2-(Methyl-{4-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzyl}-amino)-ethanol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-bis(4-methoxyphenyl)allyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 2-Oxo-nonanedioic acid 1-methylamide 9-quinolin-3-ylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-acetamidopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (1'S*,5'R*)-6-(5-Heptyl-2-Iodo-4-oxocyclopent-2-enyloxy)hexanoic Acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(2-(4-fluorophenyl)oxazol-5-yl)-N-hydroxyheptanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(2-methoxyphenyl)-2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Erbeta --- ER | 1-(2-{4-[8-Fluoro-4-(4-fluorophenyl)-2,3-dihydro-benzo[b]-oxepin-5-yl]-phenoxy}-ethyl)-pyrrolidine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)phenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(trifluoromethyl)-9H-carbazole | Drug Info |
| Erbeta --- ER | 9a-(4-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-methoxy-benzyl}-butyric acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-tert-butyl 1-(tert-butylamino)-7-mercapto-1-oxoheptan-2-ylcarbamate | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-amino-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-chloro-4-(3-(3-phenyl-7-propylbenzofuran-6-yloxy)propylthio)phenyl)acetic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-tert-butyl 7-mercapto-1-oxo-1-(quinolin-3-ylamino)heptan-2-ylcarbamate | Drug Info |
| TRIP5 --- mRNA of KIF11 | O-(trityl)-L-serine | Drug Info |
| Erbeta --- ER | (R)-9a-ethyl-6-(trifluoromethyl)-9,9a-dihydroindeno[2,1-e]indazole-7,10(3H,8H)-dione | Drug Info |
| PPAR gamma --- PPAR delta | 2-(5-(2-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)ethoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| HER2 --- MMP-1 | (5S,6S)-5-(hydroxycarbamoyl)-6-(isoindoline-2-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| Lck --- VEGFR | N-(2,3-dihydro-1H-inden-4-yl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide | Drug Info |
| Erbeta --- ER | 6-(4-Hydroxy-phenyl)-1-nitro-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | {4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid | Drug Info |
| DHODH --- IL17 | SID174007069 | Drug Info |
| Src --- VEGFR | N*2*,N*7*-Bis-[3-(4-methyl-piperazin-1-yl)-propyl]-3-phenyl-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Erbeta --- ER | 3-Bromo-4,6-dihydroxy-2-(4-hydroxy-phenyl)-inden-1-one | Drug Info |
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