Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 3,7,9-Trihydroxy-5,11-dioxa-benzo[b]fluoren-10-one | Drug Info |
| Met --- VEGFR | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-(4-(2-aza-bicyclo[2.2.1]hept-5-en-2-yl)butyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Erbeta --- ER | (2-Cyclohexyl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-2-[4-(4-tert-Butyl-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(5-chlorothiophen-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-isopropyl-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-oxo-1-(2-phenoxy-ethyl)-azepan-3-yl]-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-Fluorobenzyl)-4-furan-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-3-methyl-1,2'-spirobi[1H-indene]-5-ol | Drug Info |
| MMP1 --- MMP3 | (R)-2-[4-(4-Chloro-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | Drug Info |
| FGFR --- VEGFR | 3-(3,5-Dimethoxy-phenyl)-N*7*-[3-(4-methyl-piperazin-1-yl)-propyl]-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-5-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-(4-ethylphenyl)acetamide | Drug Info |
| Src --- VEGFR | CHEMBL199110 | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2H-chromen-7-ol | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-7-(4-methyl-piperazin-1-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR1 --- FGFR1 | Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate | Drug Info |
| Erbeta --- ER | 4-(2-(4-Cyclohexylphenylamino)ethyl)-1H-imidazole | Drug Info |
| MMP13 --- MMP1 | [4-(2-Chloro-benzyl)-benzyl]-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| VEGFR2 --- CD135 | (Z)-1-(3,4-Dimethoxyphenyl)-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]urea | Drug Info |
| Erbeta --- ER | 4-ethyl-3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-1-[4-(isoquinolin-1-ylmethoxy)-benzenesulfonyl]-3,3-dimethyl-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Erbeta --- ER | 2,3-bis(4-hydroxyphenyl)butanenitrile | Drug Info |
| MMP13 --- MMP1 | 1-(4-(4-fluorophenoxy)phenylsulfonamido)-N-hydroxycyclopentanecarboxamide | Drug Info |
| VEGFR2 --- CDK1 | 4-tert-butyl-2-(4-(2-hydroxyethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-3-(4-Hydroxy-phenyl)-4-methyl-2-{4-[(S)-2-((R)-3-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-chroman-6-ol | Drug Info |
| MMP13 --- MMP1 | (3S,4R)-4-[4-(4-Chloro-benzyloxy)-benzenesulfonyl]-3-hydroxy-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Ckit | 9-Ethyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-benzyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-fluoro-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| VEGFR2 --- Cmet | 6-(7-(2-fluoro-4-(1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)-N,N-dimethylnicotinamide | Drug Info |
| Erbeta --- ER | (2S,3S)-5-Chloro-7-hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| MMP13 --- MMP9 | 2-(N-benzyl-4-methoxyphenylsulfonamido)-N-hydroxy-3-(trifluoromethyl)benzamide | Drug Info |
| VEGFR2 --- Cmet | N1-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | Drug Info |
| Erbeta --- ER | geldanamycin-estradiol hybrid | Drug Info |
| MMP2 --- HER2 | isopropyl-(5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-3-yl(methyl)carbamate | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Erbeta --- Mcl1 | 2,3-Bis(2-furyl)quinoxaline-6-{1-[(2-pyridyl)methyl]aminocarbonyl} | Drug Info |
| MMP2 --- MMP13 | (S)-3-methyl-2-(4'-(3-methyl-4-(methylsulfonamido)benzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)butanoic acid | Drug Info |
| VEGFR2 --- CSrc | phenyl4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamate | Drug Info |
| FGFR --- PDGFR | 4-Benzoimidazol-1-yl-phenol | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-3-methylbutanamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-5-tert-butylthiophene-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methoxy-benzyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP13 | (S)-4-(4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamido)-N-methylpiperidine-1-carboxamide | Drug Info |
| VEGFR2 --- CSrc | isobutyl4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamate | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(3-methoxy-phenoxy)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(N-isobutylnaphthalene-2-sulfonamido)acetamide | Drug Info |
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