Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | methyl 3-(2-(4-(1H-imidazol-1-yl)phenyl)acetamido)thiophene-2-carboxylate | Drug Info |
| Erbeta --- ER | SID14733222 | Drug Info |
| VEGFR2 --- TEK | 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-methoxy-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylamino)picolinamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-(3-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| VEGFR2 --- TEK | 19-methyl-7-[(1E)-1-[(2-methylpropoxy)imino]ethyl]-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| JNK1 --- JNK3 | 2-(5-chloro-2-(4-methoxyphenoxy)pyridin-4-ylamino)-N-methylbenzamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| VEGFR2 --- TEK | SID124349812 | Drug Info |
| JNK1 --- JNK3 | 3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | (R)-2-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)-2-phenyl-1H-indol-3-yl)-N-(4-(4-hydroxyphenyl)butan-2-yl)acetamide | Drug Info |
| VEGFR2 --- TEK | N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}thiophene-2-carboxamide | Drug Info |
| JNK1 --- JNK3 | 4-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzoic acid | Drug Info |
| Erbeta --- ER | broussonin A | Drug Info |
| VEGFR2 --- TEK | N-(5-((2-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidine-5-carboxamide | Drug Info |
| MEP --- Cathepsin B | 1-(1-(3,5-dichlorophenyl)-3-phenylpropylidene)thiosemicarbazide | Drug Info |
| Erbeta --- ER | 3-(5-bromo-6-hydroxynaphthalen-2-yl)benzo[d]isoxazol-6-ol | Drug Info |
| VEGFR2 --- TEK | 1-methyl-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[2,5-Dioxo-1-(3-phenyl-propyl)-piperidin-4-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester | Drug Info |
| Erbeta --- ER | 8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| MEP --- Cathepsin B | 2-(p-tolyl(3-(trifluoromethyl)phenyl)methylene)hydrazinecarbothioamide | Drug Info |
| Erbeta --- ER | (2-Cyclopentyl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-3,4-dimethoxy-benzenesulfonamide | Drug Info |
| MEP --- Cathepsin B | 2-tert-Butyloxycarbonylamino-6,7-methylenedioxy-1-(4-methoxyphenyl)-2H-isoquinolin-3-one | Drug Info |
| Erbeta --- ER | 3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid [4-(2-dimethylamino-ethoxy)-phenyl]-amide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-(chlorodifluoromethoxy)phenyl)benzamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | Drug Info |
| Erbeta --- ER | 2-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-1-phenyl-ethanone | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-bromophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Met --- VEGFR | (S)-N-(4-(2-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Erbeta --- ER | 3,8-dihydroxy-1,7-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(2-(2-(pyridin-3-yl)ethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Met --- VEGFR | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide | Drug Info |
| Erbeta --- ER | 5-[4-(2-dimethylamino-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromene-2,8-diol | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-tert-butylphenyl)benzamide | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Chloro-4H-thieno[3,2-b]indole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Erbeta --- ER | 2-Phenyl-1-thiophen-2-yl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| MMP1 --- MMP3 | (4-Benzyloxycarbonylamino-butyl)-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| Erbeta --- ER | N-(3-hydroxy-4,7-dimethyl-6-oxo-6H-benzo[c]chromen-8-yl)methanesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP1 --- MMP3 | Phosphinic acid derivative | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-3,3-dimethyl-butan-2-one | Drug Info |
| VEGFR2 --- VEGFR1 | (2-((1H-indazol-5-yl)methylamino)phenyl)(1H-indazol-3-yl)methanone | Drug Info |
| MMP1 --- MMP9 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-4-dimethylamino-benzamide | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-thiophen-2-yl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-4-(3-phenyl-pyrazolo[1,5-a]pyrimidin-6-yl)-1H-pyridin-2-one | Drug Info |
| MMP1 --- MMP9 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-isonicotinamide | Drug Info |
| Erbeta --- ER | 3-(4-(3-butyl-6-hydroxy-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
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