Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PI3K gamma --- PI3K delta | CHEMBL1213085 | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Bromo-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HD6 --- HDAC2 | 4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquinoxalin-4(1H)-yl)methyl)-N-hydroxybenzamide | Drug Info |
| EGFR3 --- HER2 | 4-(4-fluorophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3S,4R)-3-(4-hydroxy-benzoylamino)-oxepan-4-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 3,5-Dichloro-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{4-[(1-pyridine-3-yl-methanoyl)-amino]-phenyl}-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyanoquinolin-6-yl)-4-morpholinobut-2-enamide | Drug Info |
| PKCA --- NPKC delta | (R)-2-{2,6-Dihydroxy-4-[(3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-ylcarbamoyl]-benzoyl}-3-hydroxy-benzoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | GW627512B | Drug Info |
| HDAC1 --- HD6 | (S)-2-(phenylmethylsulfonamido)-N-(4-phenylthiazol-2-yl)-6-(sulfamoylamino)hexanamide | Drug Info |
| EGFR3 --- HER2 | 4-amino-6-(3-chloro-4-fluorophenylamino)pyrimidine-5-carbaldehyde O-methyl oxime | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (S)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | N-Ethyl S-2-(4-methoxy-phenyl)-2-oxoethyl thiocarbamate | Drug Info |
| EGFR3 --- HER2 | 6,7-dimethoxy-4-(3-nitrophenylamino)quinoline-3-carbonitrile | Drug Info |
| PPAR delta --- LXRalpha | 2-(3-chloro-4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)phenyl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | 3-(3-(4,5-dimethyl-1-phenethyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | (4-Benzyloxy-3-chloro-phenyl)-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| PPAR gamma --- LXRalpha | 3-{3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}-N-propylbenzamide | Drug Info |
| HDAC1 --- HD6 | N-Hydroxy-8-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)octanamide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propynamide | Drug Info |
| PPAR gamma --- PPAR delta | {4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethoxy]-phenoxy}-acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-pyridin-3-ylmethyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- PKCA | K00570a | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(5-hydroxypent-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | (2S,5R)-benzyl 4-(5-((2-aminophenyl)carbamoyl)pyridin-2-yl)-2,5-dimethylpiperazine-1-carboxylate | Drug Info |
| Erbeta --- ER | 3-(4-Fluoro-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-((2-methoxy-4-(trifluoromethyl)benzamido)methyl)phenoxy)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-hydroxy-7-(4-(4-methoxyphenyl)thiazol-2-yl)heptanamide | Drug Info |
| Erbeta --- ER | (13S,17S)-4-Hydroxymethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-2-yl)phenyl)-4-methoxybenzamide | Drug Info |
| Erbeta --- ER | (S)-9a-methyl-6-(trifluoromethyl)-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-n-hexyloxy-3-[(4-trifluoromethylbenzoylamino)methyl]phenylmethyl}butyric acid | Drug Info |
| HDAC1 --- HDAC2 | Benzofuran-2-carboxylic acid (6-hydroxycarbamoyl-hexyl)-amide | Drug Info |
| Erbeta --- ER | 6-(3-Fluoro-4-hydroxy-phenyl)-2-hydroxy-naphthalene-1,4-dicarbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-chloro-4-(3-(3-ethyl-7-propylbenzofuran-6-yloxy)propylthio)phenyl)acetic acid | Drug Info |
| HDAC1 --- HDAC4 | Octanethioic acid S-[(E)-4-((5R,8S,11S)-8-isopropyl-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraaza-tricyclo[14.2.1.1*2,5*]icosa-1(18),2(20),16(19)-trien-11-yl)-but-3-enyl]ester | Drug Info |
| Erbeta --- ER | (2R,3R,4R)-3-(4-Hydroxy-phenyl)-4-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | LY-518674 | Drug Info |
| HER2 --- CD221 | trans-N-(4-(4-amino-1-(4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | 10-[4-(2-Diethylamino-ethoxy)-benzyl]-10H-benzo[4,5]thieno[3,2-b]indole-3,7-diol | Drug Info |
| PPAR gamma --- PPAR delta | 5-bromo-2-(3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HER2 --- MMP-2 | isopropyl-(5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-3-yl(methyl)carbamate | Drug Info |
| Erbeta --- ER | 2-Hydroxy-5-{[2-(2-{2-[(3-{4-[1-(4-hydroxy-phenyl)-2-phenyl-butyl]-phenoxy}-propyl)-methyl-amino]-ethoxy}-ethoxy)-ethoxyimino]-methyl}-benzamide | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(6-methoxy-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5-propyl-chroman-4-one | Drug Info |
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