Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-sulfonic acid amide | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(2-(dimethylamino)ethyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | 2-((4-((2-(dimethylamino)ethyl)oxy)-phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 2-(2,4-Dichloro-benzenesulfonyl)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 3-(9-(1-((5-chloropyridin-3-yl)methyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-4-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[3-((R)-2-Amino-3-mercapto-propylamino)-phenyl]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| NET --- SERT | CHEMBL422055 | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(2-thienylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propylamino)-2-benzyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| NET --- SERT | ((3S,4R)-1-Methyl-4-phenyl-pyrrolidin-3-yl)-pyridin-2-yl-methanone | Drug Info |
| VEGFR2 --- FGFR1 | N2-(3,5-dimorpholinophenyl)-N4-(3-methoxyphenyl)-N4-methylpyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | (S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-methyl]-3-benzyloxy-tetrahydro-pyran-2-carbonyl}-amino)-4-methanesulfinyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(2-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide | Drug Info |
| Ftase --- FPTase | 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(3-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[4-(Adamantane-1-carbonyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | (2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-one | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | N-Cyclobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(4-((2-methoxyethylamino)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| Ftase --- FPTase | 15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| CAII --- CAI | ([(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-{2-[(2-{[(2-bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-carboxymethyl-amino}-ethyl)-carboxymethyl-amino]-ethyl}-amino)-acetic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(2-cyclohexylvinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | SID124349917 | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(4-(morpholinomethyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | 9-butyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| H3 --- SERT | 3-(8-(3,4-dichlorophenyl)-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)-N,N-diethylpropan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-(4-m-Tolylamino-pyrido[3,4-d]pyrimidin-6-yl)-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone | Drug Info |
| VEGFR2 --- VEGFR1 | [4-(2-Phenyl-imidazol-1-yl)-pyrimidin-2-yl]-m-tolyl-amine | Drug Info |
| H3 --- SERT | (6S,10bR)-6-(4-(1H-pyrazol-1-yl)phenyl)-9-(3-morpholinopropoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-(1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-methyl oxime | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-[2-(3-Hydroxy-naphthalen-2-yl)-4-phenyl-oxazol-5-yl]-acetamide | Drug Info |
| H3 --- SERT | 7-(3-(azetidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Phenoxy-phenylamino)-quinazolin-6-yl]-acrylamide | Drug Info |
| CAII --- CAI | 3-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-dimethylamino-ethyl ester | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-ethyl)-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 1-[(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,6-dimethyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| CAII --- CAIX | 2,4-Diphenyl-6-propyl-1-(4-sulfamoyl-benzyl)-pyridinium; perchlorate | Drug Info |
| CAIX --- CAXII | 7-Hydroxycoumarin | Drug Info |
| CALM2 --- Cathepsin B | {3-Methyl-1-[1-(3-phenyl-propylaminooxalyl)-propylcarbamoyl]-butyl}-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(6-amino-9H-purin-9-yl)propyl)-2-oxopentanamide | Drug Info |
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