Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CSrc --- CABL | 4-((6-bromobenzo[d][1,3]dioxol-5-yl)methylene)-1-(4-iodophenyl)pyrazolidine-3,5-dione | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-benzenesulfonic acid 2-(4-sulfamoyl-phenyl)-ethyl ester | Drug Info |
| CSrc --- CABL | 3-Amino-2,6-diphenyl-2H-pyrazolo[4,3-c]pyridin-4(5H)-one | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- Ckit | 3-(2-aminoquinazolin-6-yl)-1-(4-chloro-3-fluorophenyl)-4-methylpyridin-2(1H)-one | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-sulfamoyl-phenyl)-amide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | N,N-dialkylthio-carbonylsulfenylamino derivative | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 4-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-dimethylamino-1-methyl-ethyl ester | Drug Info |
| EGFR --- HER2 | (E)-2-Cyano-3-(3,4-dihydroxy-phenyl)-N-(2,4-dimethoxy-phenyl)-acrylamide | Drug Info |
| CAII --- CAI | [(3aS,3bR,7aS,8aS)-2,2,5,5-tetramethyltetrahydro-8aH-[1,3]dioxolo[4,5]furo[3,2-d][1,3]dioxin-8a-yl]methyl aminosulfonylcarbamate | Drug Info |
| EGFR3 --- CD221 | 3-(4-Hydroxy-3-methoxy-phenyl)-2-pyridin-2-yl-acrylonitrile | Drug Info |
| CAII --- CAI | 4-{[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-methyl}-benzenesulfonamide | Drug Info |
| EGFR3 --- CSrc | (S)-N-(4-(5-chlorobenzo[d][1,3]dioxol-4-ylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide | Drug Info |
| CAII --- CAI | 1-[(2-Iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,6-dimethyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| EGFR3 --- HER2 | SID124350000 | Drug Info |
| CAII --- CAI | sodium 4-cyanobenzoate | Drug Info |
| EGFR3 --- HER2 | CHEMBL428777 | Drug Info |
| CAII --- CAI | N-(2-Chloro-4-sulfamoyl-phenyl)-2-methylamino-acetamide | Drug Info |
| EGFR3 --- HER2 | 1-(5-Bromo-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylurea | Drug Info |
| CAII --- CAI | N-(2-Diethylamino-ethyl)-3-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzamide | Drug Info |
| EGFR3 --- HER2 | SID50107157 | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| EGFR3 --- HER2 | 4-(3-bromophenylamino)-6,7-dimethoxyquinoline-3-carbaldehyde | Drug Info |
| CAII --- CAI | 4-(2-((1-methyl-1H-pyrrol-2-yl)methyleneamino)ethyl)benzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-phenylpyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(3-sulfamoyl-phenylsulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-5-(4-morpholinyl)-2-pentynamide | Drug Info |
| CAII --- CAI | 1-(3-(4-fluorophenyl)-5-sulfamoyl-1H-indole-2-carboxamido)-2,4,6-trimethylpyridinium perchlorate | Drug Info |
| CAII --- CAI | 5,10-dihydroindeno[1,2-b]indole-2,4-diol | Drug Info |
| CAII --- CAI | sodium 4-nitrobenzoate | Drug Info |
| CAII --- CAI | ((2-{Carboxymethyl-[2-(carboxymethyl-{[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenecarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenecarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide | Drug Info |
| CAII --- CAI | 4-((1R,8R,11S,12S,15S,16R,17S)-3,12-Dihydroxy-10-methyl-13-(R)-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-chloro-2,4-disulfamoyl-phenyl)-amide | Drug Info |
| CAII --- CAI | 5-[4-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonylamino]-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CAII --- CAIX | 2-oxo-2H-thiochromene-3-carboxylic acid | Drug Info |
| CAIX --- CAXII | 6-(allyloxy)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(2-Hydroxy-ethylaminooxalyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | {3-Methyl-1-[1-(pyridin-2-ylmethyl)-aminooxalyl]-butylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(5-Hydroxy-1,3,3-trimethyl-cyclohexylmethyl)-aminooxalyl]-propylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-2-amino-N-((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)pentanamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclohexyl-1-oxo-1-(2-(4-(trifluoromethoxy)phenylamino)ethylamino)propan-2-yl)-5-(3-(trifluoromethyl)phenyl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(5-chloroindolin-1-yl)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | N-{(S)-1-[2-(4-Cyclopentylmethoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-4-methoxy-benzamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-1,3-dimethyl-1H-pyrazole-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | CHEMBL450061 | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((3R,4S)-2-Oxo-4-phenylsulfanyl-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
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