Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- MEP | 1-(2-Chloro-phenyl)-1H-[1,2,4]triazole-3-carboxylic acid {1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | 4-Methoxy-N-{1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-benzamide | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(4-(methylsulfonyl)phenylamino)propan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | (S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-pentanoic acid (cyano-dicyclopropyl-methyl)-amide | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(5-fluoro-3,3-dimethylindolin-1-yl)propan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | 9-Cyclopentyl-6-{2-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenylamino}-9H-purine-2-carbonitrile | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(3-bromo-4-chlorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(6-hydroxy-naphthalene-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-dimethylamino-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | (R)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-phenylpropanoic acid | Drug Info |
| CCKBR --- CCKAR | (S)-2-[3-(3-Methoxy-phenyl)-ureido]-5-oxo-5-pyrrolidin-1-yl-pentanoic acid dipentylamide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-8-methyl-2-oxo-5-phenyl-3-[3-(3-phenylmethanesulfonylaminocarbonyl-phenyl)-ureido]-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-fluoro-phenyl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 1-{(R)-1-[(R)-(4-Benzoyl-piperidin-1-yl)-oxo-methyl]-2-benzyloxy-propyl}-3-m-tolyl-urea | Drug Info |
| CCKBR --- CCKAR | 2-((3R,5S)-5-Benzyl-8-methyl-2-oxo-3-{3-[3-(1H-tetrazol-5-yl)-phenyl]-ureido}-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-N-tert-butyl-acetamide | Drug Info |
| CCKBR --- CCKAR | (S)-3-[(S)-2-[2-((S)-3-tert-Butyl-ureido)-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[(S)-2-(2-dimethylamino-acetylamino)-3-1H-indol-3-yl-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CD135 --- Ckit | N3-(4-(1-methylpiperidin-4-yl)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine | Drug Info |
| CD221 --- JNK1 | GSK1713088A | Drug Info |
| CDK1 --- CDK2 | 4-[(2-Oxo-1,2-dihydro-indol-3-ylidenemethyl)-amino]-N-thiazol-2-yl-benzenesulfonamide | Drug Info |
| CDK1 --- CDK2 | GW416469X | Drug Info |
| CDK1 --- Cyclin E | 6-(4-Amino-benzenesulfonyl)-pyrimidin-4-ylamine | Drug Info |
| CDK1 --- GSK3 | K00192 | Drug Info |
| CDK1 --- GSK3 | 6-(4-Chloro-phenyl)-7-cyclohexylmethyl-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | 3-{5-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylamino)-[1,3,5]triazin-2-yl]-pyridin-3-ylamino}-propan-1-ol | Drug Info |
| CDK2 --- AKT | SID103905150 | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-methylbenzamide | Drug Info |
| CDK2 --- CDK1 | N-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonyl)-2-(2-methoxyethoxy)acetamide | Drug Info |
| CDK2 --- CDK1 | 4-{N'-[7-oxo-6,7-dihydro-3H-pyrrolo[3',2':3,4]benzo[1,2-d][1,2,3]triazol-(8Z)-ylidene]-hydrazino}-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | SID124893605 | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-methylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | N-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-N-methyl-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | (6-Cyclohexylmethoxy-9H-purin-2-yl)-(4-methanesulfinyl-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL485618 | Drug Info |
| CDK2 --- CDK4 | N-(4-nitrophenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- CDK4 | [4-(5-Chloro-2,4-dimethyl-1H-pyrrol-3-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine | Drug Info |
| CDK2 --- CSrc | N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-(2-trifluoromethyl-quinazolin-4-yl)-amine | Drug Info |
| CDK2 --- Cyclin E | ((R)-1-Phenyl-ethyl)-(2-trifluoromethyl-quinazolin-4-yl)-amine | Drug Info |
| CDK2 --- Cyclin E | Indenopyrazoles derivative | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((6-(thiophen-2-yl)pyridin-3-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | (1,1-Dimethyl-propyl)-(2-trifluoromethyl-quinazolin-4-yl)-amine | Drug Info |
| CDK2 --- Cyclin E | N6-(4-(1H-pyrrol-1-yl)benzyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-3-yl)benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | N-(6-(4-hydroxyphenyl)-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(4-Methyl-[1,4]diazepane-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 2-Amino-N-[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide | Drug Info |
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