Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| EGFR3 --- CSrc | N-(2,6-dimethylphenyl)-5-[4-(1-methylpiperidin-3-ylmethoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine hydrochloride | Drug Info |
| CAII --- CAI | 2-(pyridin-2-yl)-N-(4-sulfamoylphenyl)acetamide | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid piperidin-3-ylmethyl ester | Drug Info |
| CAII --- CAI | (S)-3-(1H-Indol-3-yl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(4-benzyloxy-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide | Drug Info |
| CAII --- CAI | 2-Amino-N-[(2-bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-acetamide | Drug Info |
| EGFR3 --- HER2 | 1-(2-(4-(3-methoxy-4-(pyridin-2-ylmethoxy)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yloxy)ethyl)piperidin-4-ol | Drug Info |
| CAII --- CAI | 3-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-dimethylamino-ethyl ester | Drug Info |
| EGFR3 --- HER2 | 2-(3-(4-Chlorophenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| CAII --- CAI | 4-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | (R)-N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-((1-(methylsulfonyl)pyrrolidin-2-yl)ethynyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 3-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-hydroxy-ethyl ester | Drug Info |
| EGFR3 --- HER2 | TCMDC-135468 | Drug Info |
| CAII --- CAI | {[2-(4-Sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-((3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl)ethanesulfonamide | Drug Info |
| CAII --- CAI | (2S,3S)-3-Methyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-pentanoic acid | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-benzoic acid 4-sulfamoyl-benzyl ester | Drug Info |
| CAII --- CAI | 4-Carbamoyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-butyric acid (S)-methylcarbamoylmethyl with resin | Drug Info |
| CAII --- CAI | 4-Methyl-5-(4-trifluoromethanesulfonylamino-benzenesulfonylimino)-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CAII --- CAI | {[2-(Bis-carboxymethyl-amino)-ethyl]-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 4-Benzoyl-1-(3-((1,3-dioxo-1,3-diphenylpropan-2-yl)diazenyl)phenyl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| CAII --- CAI | (2-{[(2-Sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| CAII --- CAI | 5-[4-(4-Bromo-benzenesulfonyl)-phenyl]-4-(4-methoxy-phenyl)-4H-[1,2,4]triazole-3-thiol | Drug Info |
| CAII --- CAIX | 4-((3-(2-phenylcyclopropyl)ureido)methyl)benzenesulfonamide | Drug Info |
| CAIX --- CAXII | Sodium phenylaminomethanesulfonate | Drug Info |
| CALM2 --- Cathepsin B | 3-[4-Methyl-2-(2-naphthalen-1-yl-acetylamino)-pentanoylamino]-2-oxo-pentanoic acid ethylamide | Drug Info |
| CALM2 --- Cathepsin B | (R)-1-(3-nitrophenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide | Drug Info |
| CALM2 --- Cathepsin B | (S)-2-ethyl-N-(1-oxo-3-phenylpropan-2-yl)-2-(3-phenylpropanamido)butanamide | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Cyclohexyl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-2-(7-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-(2-(4-fluorophenylamino)ethyl)propanamide | Drug Info |
| Cathepsin K --- MEP | [1-((3S,4S)-2-Oxo-4-phenoxy-azetidin-3-ylcarbamoyl)-cyclohexyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 3-Acetyl-N-[1-(2S-ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | [1-(1-Acetyl-4-oxo-pyrrolidin-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-{(S)-2-Cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-4-(4,6-dimethyl-pyrimidin-2-ylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | pyrrolidine-1-carbonitrile | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(indolin-1-yl)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((2S,3S)-2-Butoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | 3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyclohexyl-8-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-ureido}-benzoic acid methyl ester | Drug Info |
| CCKBR --- CCKAR | (S)-3-((S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)hexanamido)-4-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-4-oxobutanoic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-(2-{1-[2-(2-tert-Butoxycarbonylamino-3-carboxy-propionylamino)-3-(4-sulfooxy-phenyl)-propionylamino]-pentylcarbamoyl}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-tert-Butoxycarbonylamino-N-[1-[1-({[1-{1-[2-carboxy-1-(3-phenyl-propionylamino)-ethylcarbamoyl]-pentylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-pentylcarbamoyl]-2-(4-sulfooxy-phenyl)-ethyl]-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 2-Amino-4-chloro-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide | Drug Info |
| CCKBR --- CCKAR | (R)-5-Fluoro-1H-indole-2-carboxylic acid [1-dipentylcarbamoyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chloro-N-phenethylbenzamide | Drug Info |
| CCKBR --- CCKAR | 3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-5-cyclohexyl-8-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-ureido}-benzoic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-((3R,5R)-5-isopropyl-8-methyl-2-oxo-3-{3-[3-(1H-tetrazol-5-yl)-phenyl]-ureido}-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-trifluoromethyl-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | [(S)-1-[(S)-1-(4-Benzoyl-piperidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester | Drug Info |
| CD221 --- JNK1 | 2-(2-(5-(2-(dimethylamino)acetamido)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
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