Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-2-((dimethylamino)methyl)acrylamide | Drug Info |
| CAII --- CAI | 6-[2-(4-Sulfamoyl-phenyl)-ethylcarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid trans-2-piperidin-4-ylethyl ester | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-sulfamoyl-benzothiazol-6-yl)-acetamide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methylcarbamate | Drug Info |
| CAII --- CAI | phenylarsonic acid | Drug Info |
| EGFR3 --- HER2 | GW784684X | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| EGFR3 --- HER2 | (7-Allyloxy-6-methoxyquinazolin-4-yl)-(3'-bromophenyl)amine hydrochloride | Drug Info |
| CAII --- CAI | 2-(3-chloro-4-hydroxyphenyl)-N-phenethylacetamide | Drug Info |
| EGFR3 --- HER2 | 4-[(4'-fluorobenzyl)amino]-6,7-diethoxyquinazoline hydrochloride | Drug Info |
| CAII --- CAI | Ethyl1-(2-methyl-1-(2-oxopropyl)-1H-indol-4-yl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1Hpyrazole-4-carboxylate | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Chloro-4-fluorophenylamino)quinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| CAII --- CAI | {[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 3-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | 4-(2-Trifluoromethanesulfonylamino-pyrimidin-4-ylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | [{2-[[(5-Chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| CAII --- CAI | 4-Carbamoyl-2-(4-sulfamoyl-benzoylamino)-butyric acid | Drug Info |
| CAII --- CAI | 2,6-Diethyl-4-phenyl-1-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
| CAII --- CAI | 4-(N'-Pentafluorobenzoyl-hydrazino)-benzenesulfonamide | Drug Info |
| CAII --- CAIX | 1-[2-(4-sulfamoylphenyl)ethyl]-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea | Drug Info |
| CAIX --- CAXII | 6-(hydroxymethyl)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-((S)-5-Benzenesulfonylamino-1-formyl-pentyl)-3-benzyloxy-2-methanesulfonylamino-propionamide | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonylamino-4-phenyl-butyramide | Drug Info |
| CALM2 --- Cathepsin B | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(6-amino-2-methoxy-9H-purin-9-yl)propyl)-2-oxophenylbutanamide | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Thiophen-2-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclopentyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxobutan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-pentanoic acid ((S)-cyano-methyl-methyl)-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | (R)-2-{3'-[2-(3-dimethylamino-pyrrolidin-1-yl)-thiazol-4-yl]-biphenyl-yl}-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | (S)-2-(6-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(5-fluoroindolin-1-yl)-4-(methylsulfonyl)butan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | 2-[2-(2-Biphenyl-4-yl-acetylamino)-3-mercapto-propionylamino]-5-guanidino-pentanoic acid [2-(4-hydroxy-phenyl)-1-phenethylcarbamoyl-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-2-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[3-(2-imidazol-1-yl-ethoxy)-4-methoxy-phenyl]-ethyl}-amide | Drug Info |
| CCKBR --- CCKAR | {[2-(Adamantan-2-yloxycarbonylamino)-2-methyl-3-naphthalen-1-yl-propionyl]-phenethyl-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(4-chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-Boc | Drug Info |
| CCKBR --- CCKAR | [3H]Propionyl-BC264 | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-5-cyclohexyl-8-methyl-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-{3-[(3R,5R)-1-(tert-Butylcarbamoyl-methyl)-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-ureido}-benzoic acid | Drug Info |
| CCKBR --- CCKAR | H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H | Drug Info |
| CCKBR --- CCKAR | 1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-5-cyclohexyl-3-[3-(3-methanesulfonylaminocarbonyl-phenyl)-ureido]-8-methyl-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(3,4-dichlorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-isopropyl-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-(2-(1H-imidazol-1-yl)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(5-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)pyridin-2-yl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 3-[9-Ethyl-2-(4-hydroxy-cyclohexylamino)-9H-purin-6-ylamino]-benzonitrile | Drug Info |
| CDK1 --- CDK4 | 6-Benzylamino-2-[(1R)-1-ethyl-2-hydroxy-2-methylpropylamino]-9-isopropylpurine | Drug Info |
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