Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CSrc --- Ckit | 3-(2-aminoquinazolin-6-yl)-1-(4-chlorophenyl)-4-methylpyridin-2(1H)-one | Drug Info |
| CAII --- CAI | 4-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-3-iodo-benzenesulfonamide | Drug Info |
| DHFR --- TYMS | 4-[4-(4-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-4-carboxy-butyric acid anion | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid compound with Zn complex | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | 2-Propyl-pentanoic acid (3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-amide | Drug Info |
| EGFR --- HER2 | N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-2-methyl-acrylamide | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- CABL | (3-Bromo-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine | Drug Info |
| CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide | Drug Info |
| EGFR3 --- CSrc | 2-(2-(4-amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanol | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-{[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
| EGFR3 --- HER2 | 4-(3-bromophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 2-Amino-N-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-acetamide | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-bromophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| CAII --- CAI | {[(5-Chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| EGFR3 --- HER2 | [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid,(3S)-3-morpholinylmethyl ester | Drug Info |
| CAII --- CAI | 2-methylcyclohexanone | Drug Info |
| EGFR3 --- HER2 | 1-(2-chloroethyl)-3-{[4-(3-methylphenyl)amino]quinazolin-6-yl}urea | Drug Info |
| CAII --- CAI | (S)-4-Methylsulfanyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-butyric acid methylcarbamoylmethyl with resin | Drug Info |
| EGFR3 --- HER2 | 5-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxypentanamide | Drug Info |
| CAII --- CAI | sodium 4-iodobenzoate | Drug Info |
| EGFR3 --- HER2 | (R)-methyl 2-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidine-1-carboxylate | Drug Info |
| CAII --- CAI | ethyl 2-chloro-4-{[5-chloro-4-(ethoxycarbonyl)-2-sulfamoylphenyl]disulfanyl}-5-sulfamoylbenzoate | Drug Info |
| EGFR3 --- HER2 | (1-Benzyl-1H-indazol-5-yl)-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| CAII --- CAI | 2-Amino-N-[2-(4-hydroxymethyl-benzenesulfonylamino)-2-oxo-ethyl]-acetamide | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 4-Benzoyl-1-(2-methyl-1-(2-oxopropyl)-1H-indol-4-yl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| CAII --- CAI | N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-3-trifluoromethanesulfonylamino-propionamide | Drug Info |
| CAII --- CAI | 3-Phenyl-2-(4-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| CAII --- CAI | 3-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-dimethylamino-ethyl ester | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-ethyl)-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 1-[(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,6-dimethyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| CAII --- CAIX | 2,4-Diphenyl-6-propyl-1-(4-sulfamoyl-benzyl)-pyridinium; perchlorate | Drug Info |
| CAIX --- CAXII | 7-Hydroxycoumarin | Drug Info |
| CALM2 --- Cathepsin B | {3-Methyl-1-[1-(3-phenyl-propylaminooxalyl)-propylcarbamoyl]-butyl}-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(6-amino-9H-purin-9-yl)propyl)-2-oxopentanamide | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(Furan-2-ylmethyl)-aminooxalyl]-propylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | N-Cyanomethyl-3-cyclobutyl-2-[4'-(4-methyl-piperazin-1-yl)-biphenyl-3-yl]-propionamide | Drug Info |
| Cathepsin K --- MEP | (R)-2-(cyclohexylmethyl)-4-morpholino-4-oxo-N-((S)-4-phenyl-1-(4-(trifluoromethoxy)phenylamino)butan-2-yl)butanamide | Drug Info |
| Cathepsin K --- MEP | (R,S)-4-methyl-2-{3'-[2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-biphenyl-3-yl}-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-cyclohexyl-1-oxo-1-(2-(4-(trifluoromethoxy)phenylamino)ethylamino)propan-2-yl)benzofuran-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | 4-Methyl-2-(3-pyridin-3-yl-phenyl)-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-((cyclohexylmethyl)(methyl)amino)-N-phenethylpyrimidine-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | [3-Methyl-1-(3-oxo-tetrahydro-pyran-4-ylcarbamoyl)-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | {(S)-1-[(S)-1-Benzyl-2-(biphenyl-4-ylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-3-cyclohexyl-1-morpholino-1-oxopropan-2-yl (S)-1-(4-(trifluoromethoxy)phenylamino)pentan-2-ylcarbamate | Drug Info |
| CCKBR --- CCKAR | [(R)-2-(1H-Indol-3-yl)-1-methyl-1-phenylcarbamoyl-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5R)-2-oxo-5-phenyl-3-(3-p-tolyl-ureido)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-tert-Butoxycarbonylamino-N-[1-[1-({[1-{1-[1-(2-carbamoyl-3-phenyl-propionylamino)-2-carboxy-ethylcarbamoyl]-pentylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-pentylcarbamoyl]-2-(4-sulfooxy-phenyl)-ethyl]-succinamic acid | Drug Info |
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