Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CAII --- CAI | [(2-Hydroxy-phenyl)-(2-{(2-hydroxy-phenyl)-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-acetic acid | Drug Info |
| CAII --- CAIX | 4-(2-((2,4-Diaminopteridin-6-yl)methylamino)ethyl)benzenesulfonamide | Drug Info |
| CAII --- CAIX | Sulfamic acid but-3-ynyl ester | Drug Info |
| CAIX --- CAXII | 7-(2'-fluoroethoxy)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2-naphthalen-1-yl-vinyl)-benzamide | Drug Info |
| CALM2 --- Cathepsin B | {1-[1-(Isoquinolin-1-ylmethyl)-aminooxalyl]-propylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | CHEMBL3039860 | Drug Info |
| Cathepsin K --- Cathepsin B | tert-butyl 1-(((S)-1-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl)carbamoyl)cyclohexylcarbamate | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-cyclohexylamino-pyrimidine-5-carboxylic acid {2-[4-(4-methylpiperazin-1-yl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | [(S)-1-((2S,3S)-2-Benzyloxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 5-Bromo-4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-6-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | benzyl (S)-1-((S)-1-cyano-2-(4-methoxyphenyl)ethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-(1,3,4-thiadiazol-2-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-3-tert-butyl-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-3-tert-butyl-N-(1-(cyanomethylamino)-3-(3-(5-(methoxymethyl)-1,3,4-oxadiazol-2-yl)phenyl)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-{(S)-3-Cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-propyl}-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | 6-(cyclohexylamino)-9-(2-(4-methylpiperazin-1-yl)ethyl)-9H-purine-2-carbonitrile | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[(6-hydroxy-naphthalene-2-carbonyl)-amino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | [1-[2-(4-Chloro-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | [3H]L-365260 | Drug Info |
| CCKBR --- CCKAR | (2R,3R)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chlorobenzamido)-3-(3,4-dichlorophenyl)butanoic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-[(3R,5S,7R)-7-(4-fluoro-phenyl)-2-oxo-5-phenyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide | Drug Info |
| CCKBR --- CCKAR | Boc-Tyr(So3-)-Nle-Gly-Trp-Nle-psi(CH2NH)-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-trifluoromethyl-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-ethanesulfonylaminocarbonyl-phenyl)-ureido]-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-(2-Amino-3-phenyl-propionylamino)-N-(1-{[1-tert-butoxycarbonyl-2-(1H-indol-3-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-thiophen-2-yl-acryloylamino)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CD221 --- JNK1 | 2-(2-(5-(2-(dimethylamino)-N-methylacetamido)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(2-morpholinoethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | (Z)-4-(2-(6-ethyl-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- CDK4 | 6-Benzylamino-2-[(1R,2RS)-1-ethyl-2-hydroxypropylamino]-9-isopropylpurine | Drug Info |
| CDK1 --- GSK3 | 7-Cyclopropylmethyl-6-(4-methoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- GSK3 | 3-(6-Oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-benzo[2,3]azepino[4,5-b]indol-2-yl)-propionitrile | Drug Info |
| CDK1 --- HER2 | N-methyl(5-(3-(5-(trifluoromethoxy)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)methanamine | Drug Info |
| CDK2 --- AKT | (2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl)((S)-3-aminopyrrolidin-1-yl)methanone | Drug Info |
| CDK2 --- AuroraA | N-cyclopropyl-1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | 8-{[3-(Dimethylamino)phenyl]amino}-N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CD221 | CHEMBL1809194 | Drug Info |
| CDK2 --- CDK1 | 4-[6-Amino-5-(2,6-difluoro-benzoyl)-pyridin-2-ylamino]-N,N-dimethyl-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxo-4-phenoxyindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | SID124349847 | Drug Info |
| CDK2 --- CDK1 | N-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 6-Cyclohexylmethoxy-N*2*-(4-methoxy-phenyl)-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK1 | GW300660X | Drug Info |
| CDK2 --- CDK4 | 4-[2-(3-Hydroxy-phenylamino)-pyrimidin-4-yl]-3,5-dimethyl-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | TCMDC-138697 | Drug Info |
| CDK2 --- CDK4 | CHEMBL317629 | Drug Info |
| CDK2 --- CDK4 | CHEMBL478409 | Drug Info |
| CDK2 --- Cyclin E | 2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | 6-Benzyl-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
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