Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CD221 --- JNK1 | 2-(2-(5-(3-(dimethylamino)propyl)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)-N-(2-hydroxyethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid amide | Drug Info |
| CDK1 --- CDK4 | (5-Piperazin-1-yl-pyridin-2-yl)-[4-(3-trifluoromethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CDK1 --- GSK3 | (E)-3-(6-Oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-benzo[2,3]azepino[4,5-b]indol-2-yl)-acrylic acid methyl ester | Drug Info |
| CDK1 --- GSK3 | 7-Butyl-6-(4-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- VEGFR | N-(3-chlorophenyl)-6-(5-{[3-(piperidin-1-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one | Drug Info |
| CDK2 --- AuroraA | 1-Cyclohexyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N,1-dimethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CD221 | 1-(4-(4-(5-chloro-4-(7-methoxyimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)-3-methoxyphenyl)piperazin-1-yl)ethanone | Drug Info |
| CDK2 --- CDK1 | N6-benzyl-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- CDK1 | N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide | Drug Info |
| CDK2 --- CDK1 | 4-[5-(3-Methanesulfonylamino-phenyl)-2H-pyrazol-3-ylamino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-[2-(2-Hydroxy-ethoxy)-ethyl]-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic Acid(4-Fluoro-phenyl)-amide | Drug Info |
| CDK2 --- CDK1 | 6-Cyclohexylmethoxy-N*2*-(4-methylsulfanyl-phenyl)-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK4 | [4-(6-Methyl-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL433068 | Drug Info |
| CDK2 --- CDK4 | 3-((2,5-Dichloro-phenyl)-{2-[4-(3-dimethylamino-2-hydroxy-propoxy)-phenylamino]-pyrimidin-4-yl}-amino)-propionitrile | Drug Info |
| CDK2 --- CDK4 | 1-{4-[4-(2-Chloro-phenylamino)-pyrimidin-2-ylamino]-phenoxy}-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- Cyclin E | 2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol | Drug Info |
| CDK2 --- Cyclin E | 1-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-piperidin-4-ol | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-(pyridin-2-yl)thiophen-2-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-((S)-3-hydroxy-but-1-ynyl)-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(Biphenyl-4-ylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N-(4-Fluorobenzyl)-2-(trifluoromethyl)quinazolin-4-amine | Drug Info |
| CDK2 --- Cyclin E | 7-fluoro-5-(2-fluorophenyl)-3-methyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- GSK3 | N-(5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | Ethyl-2-((3-(4-benzoyl-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1H-pyrazol-1-yl)phenyl)diazenyl)-3-oxo-3-phenylpropanoate | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(3-Amino-pyrrolidine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | N-[2-({2-[(aminosulfonyl)amino]ethyl}dithio)ethyl]sulfamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(3-methoxypropyl)picolinamide | Drug Info |
| CAII --- CAI | 4,6-Dinitro salicylic acid | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-(diethylamino)ethyl)picolinamide | Drug Info |
| CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-sulfamoyl-benzothiazol-6-yl ester | Drug Info |
| COX2 --- 5LOX | 4-[2-(4-Chloro-phenyl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | N-(2,3-Dichloro-4,6-disulfamoyl-phenyl)-2-methylamino-acetamide | Drug Info |
| COX2 --- 5LOX | BW-755C | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| COX2 --- HRH1 | 11-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethylsulfanyl}-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | 2-(N-Methyl-guanidino)-N-(4-sulfamoyl-benzyl)-acetamide | Drug Info |
| CSrc --- CABL | 3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-hydroxy-ethyl ester | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-methoxy-9H-purin-6-amine | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-ethyl)-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | N-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-4-fluorobenzamide | Drug Info |
| CAII --- CAI | 2-phenyl-N-(4-sulfamoylphenethyl)acetamide | Drug Info |
| CSrc --- CABL | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-yloxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | {4-Methyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-pentanoylamino}-acetic acid | Drug Info |
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