Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-[4-(3'-methoxy-2-methyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Amino-1-[3-(2-chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-butan-1-one | Drug Info |
| Ftase --- FPTase | 2-[2-(3-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP3 | N-[2-(4'-Cyano-biphenyl-4-yloxy)-ethyl]-N-hydroxy-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-(4-benzamidobutyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoylamino)-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-ylcarbamoyl)-propylcarbamoyl]-6-(4'-fluoro-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4-(1,3-benzodioxol-5-yl)phenyl]sulfamide | Drug Info |
| Ftase --- FPTase | 3-alFPP | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2,3'-dimethyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-(trifluoromethyl)-4-biphenylyl sulfamate | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| MMP2 --- MMP9 | rac-N,2-dihydroxy-2-methyl-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Phenyl-6-methyl-N-(4-methoxyphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP9 | 2-[7-(3,5-Dichloro-benzyloxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-3-methylbutanamide | Drug Info |
| Ftase --- FPTase | 1-((2R,3R)-3-Allyloxy-6-chloro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl)-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | (S)-1-(biphenyl-4-ylsulfonyl)-N-hydroxy-5-oxopyrrolidine-2-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-((4-methoxyphenyl)diphenylmethylthio)ethanamine | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(2-Methyl-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(2-(4-methoxyphenyl)ethynyl)phenyl)methan-8-ylsulfonamido)propanamide | Drug Info |
| DHFR --- VEGFR | (Z)-5-(2-(naphthalen-1-yl)prop-1-enyl)furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | (2E,6E)-3-ethyl-7,11-dimethyldodeca-2,6,10-trienyl trihydrogen diphosphate | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-((R)-1-phenylethylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentanoic acid | Drug Info |
| VEGFR1 --- FGFR1 | 3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | 2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)benzenesulfonamide | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-methoxy-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-2-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Methyl-benzoylamino)-benzenesulfonylamino]-3-phenyl-propionic acid | Drug Info |
| VEGFR2 --- CDK1 | 3-{4-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-propan-1-ol | Drug Info |
| Ftase --- FPTase | (+)4-{2-[4-(4-chloro-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethynyl)-benzenesulfonylamino]-propionic acid | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-6-yl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propionylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-(3'-methyl-biphenyl-4-ylmethyl)-succinamide | Drug Info |
| VEGFR2 --- CDK2 | 1-[4-(2-Hydroxy-ethyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-6,7-dihydro-2H-pyrano[3,4-c]pyrrol-4-one | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic 28 (FTI-2347) | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | 1-(3-fluoro-4-(2-(pyrimidin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| Ftase --- FPTase | Chaetomellic acid B | Drug Info |
| MMP3 --- MMP8 | 2-(5-Pyridin-2-yl-thiophen-2-ylmethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methyl-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylcarbamoyl)-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(2-Pyridin-4-yl-ethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
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