Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-(3,3-difluoropyrrolidin-1-yl)propyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2-Methyl-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine | Drug Info |
| NPKCdelta --- NPKCtheta | 1-((4-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl)phenyl)thiophen-2-yl)methyl)-4-methylpiperazine | Drug Info |
| Ftase --- FPTase | 1-[(1R,2R)-1-(2-Chloro-thiophen-3-ylmethoxy)-1,2,6,7,8,9-hexahydro-naphtho[2,1-b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[3-(2,5-Difluoro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(2-methoxystyryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| GSK --- VEGFR | 2-Cyclopentyl-N-[6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-yl]-acetamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-3-yl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)furan-2-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N',N'-dimethylacrylohydrazide | Drug Info |
| H3 --- SERT | 4-(4-chlorophenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-3-(1H-imidazol-4-yl)-acrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(3-chloro-4-fluorophenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4-hydroxy-5-methoxy-1H-benzimidazole | Drug Info |
| H3 --- SERT | N-methyl(5-(4-morpholinobut-1-ynyl)-2-phenoxyphenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-4-methyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-morpholino-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 1-(5-Chloro-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylthiourea | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(Trifluoromethyl)-3,9-dihydropyrrolo[2,3-b]carbazol-2(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957840 | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl ethyl carbonate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-4-(2,5-difluorophenyl)-2-(3-(ethylamino)propyl)-N,N-dimethyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(3-aminopropyl)-3-methyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| HD6 --- HDAC4 | 6-((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl)-N-hydroxyhexanamide | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(2-(4-methoxyphenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | N-(4-(o-tolylamino)quinazolin-6-yl)acrylamide | Drug Info |
| Lck --- VEGFR | 1-(2-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamido)-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-1-(toluene-4-sulfonyl)-azepan-4-yl ester | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(6-fluoroquinolin-4-yloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| Src --- VEGFR | Benzofuran-7-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-methanesulfonyl-cyclopentyl ester | Drug Info |
| HDAC1 --- HD6 | N1-hydroxy-N8-(4-((2R,4S,6R)-4-phenyl-6-((pyridin-4-ylthio)methyl)-1,3-dioxan-2-yl)phenyl)octanediamide | Drug Info |
| EGFR3 --- HER2 | CHEMBL258282 | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-N-methyl-N-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-5-amine | Drug Info |
| PKCA --- NPKCtheta | 3-(5-(4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | SID85267487 | Drug Info |
| VEGFR2 --- Beta PDGFR | N4-(4-Chlorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| PPAR gamma --- LXRalpha | 2-(5-((3-(8-(trifluoromethyl)quinolin-4-yl)phenyl)methylamino)naphthalen-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-(4-{[(1-phenyl-methanoyl)-amino]-methyl}-phenyl)-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N4-(3-bromophenyl)-N6-methylquinazoline-4,6-diamine | Drug Info |
| VEGFR2 --- CDK1 | 2-(3-methoxy-4-(pyrrolidin-1-ylmethyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 5-methyl-2-(3-(6-methyl-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
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