Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-carbaldehyde oxime | Drug Info |
| JNK1 --- JNK3 | 2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl)thiophen-3-yl)acetamide | Drug Info |
| PR --- mRNA of AR | 9-Chloro-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 6-chloro-2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MEP --- Cathepsin B | 4'-(Piperazine-1-sulfonyl)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(4-(trifluoromethyl)phenyl)-1-(4-methoxyphenyl)propan-1-one | Drug Info |
| Erbeta --- ER | 6-(2-hydroxyphenyl)naphthalen-2-ol | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-m-tolyl-ureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | rac-5,7-difluoro-3-hydroxy-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-methyl oxime | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-((R)-1-methyl-2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MEP --- Cathepsin B | 5-[(R)-2-Cyano-2-((S)-2-phenylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-2-fluoro-benzoic acid | Drug Info |
| PR --- mRNA of AR | 4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-thiophene-2-carbonitrile | Drug Info |
| Erbeta --- ER | 2-(3-Fluoro-4-hydroxy-phenyl)-7-furan-2-yl-benzooxazol-5-ol | Drug Info |
| MEP --- Cathepsin B | benzyl (S)-1-((S)-4-(benzylthio)-3-oxo-1-phenylbutan-2-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate | Drug Info |
| PR --- mRNA of AR | 6,8,8-Trimethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | trans-2,2-Dimethyl-3-phenyl-4-p-(beta-pyrrolidiiioethoxyphenyl)-7-methoxychroman | Drug Info |
| MEP --- Cathepsin B | (S)-N-(3-(3-(1H-pyrazol-5-yl)phenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)benzamide | Drug Info |
| PR --- mRNA of AR | (Z)-5-(4-fluoro-2-((methoxymethoxy)methyl)benzylidene)-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-chromeno[3,4-f]quinolin-9-ol | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| Met --- VEGFR | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-fluorophenyl)-2-oxoimidazolidine-1-carboxamide | Drug Info |
| PR --- mRNA of AR | 4-(2-Fluorophenylthio)-2-(trifluoromethyl)benzonitrile | Drug Info |
| Erbeta --- ER | 4-{1-Chloro-2-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-2-methoxy-phenol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Renin --- Cathepsin D | (S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methyl)-2-{(S)-2-hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-2,15-dioxo-4-phenyl-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-3-methyl-butyramide | Drug Info |
| Erbeta --- ER | 7-allyl-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(5-(4-chlorophenyl)thiophene-2-sulfonamido)-2-methyl-3-phenylcyclopropanecarboxylic acid | Drug Info |
| Renin --- Cathepsin D | (R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 4-{2-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylamino)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-3-methyl-1-(6-trifluoromethyl-1H-benzoimidazol-2-yl)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-isopropyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(2-Chloro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| MMP1 --- MMP3 | (2R)-2-{hexyl[methyl(phenyl)phosphoryl]amino}-N-hydroxypropanamide | Drug Info |
| S5AR --- SRD5A2 | 1-Methyl-5-[4-((E)-styryl)-phenyl]-piperidin-2-one | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2,5-dipropylphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| MMP1 --- MMP8 | (2R,3S)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-isobutyl-3-[(quinolin-8-ylmethyl)-amino]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a ,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-1-ylamide | Drug Info |
| Erbeta --- ER | 2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde oxime | Drug Info |
| MMP1 --- MMP9 | (R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl)-2-[(S)-3-methyl-1-(methylcarbamoylmethyl-carbamoyl)-butylamino]-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 23-azido-2,3-dehydrosilybin | Drug Info |
| MMP13 --- MMP1 | (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-acetic Acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(bis(4-chlorophenyl)methyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-4,7-dimethyl-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | 1-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-cyclobutanecarboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N,5-triethyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-9a-isobutyl-4-methyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| MMP13 --- MMP1 | 4-(4'-Fluoro-biphenyl-4-sulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-7-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | {4-[4-(4,6-Dimethyl-pyrimidin-2-yl)-piperazin-1-yl]-phenyl}-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-methanone | Drug Info |
| MMP13 --- MMP1 | (4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-m-tolyl-butyl]-phosphinic acid | Drug Info |
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