Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP9 --- MMP3 | 3-(Formyl-hydroxy-amino)-2-isobutyl-hexanoic acid [4-{[amino-(pyridine-2-sulfonylimino)-methyl]-amino}-1-(thiazol-2-ylcarbamoyl)-butyl]-amide | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-cyclohexylmethyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- AKT | N-(2-Chloro-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-phenyl-piperidine-1-carboxamidine | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-methyl-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid (3,4-dichloro-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide | Drug Info |
| mTOR --- PI3K gamma | (S)-N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-morpholino-6-((tetrahydrofuran-3-yl)oxy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
| Ftase --- FPTase | 4-((2R,3R)-6-Chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-5-methyl-3-phenyl-isoxazole | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-(dimethylamino)ethoxy)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen-2-ylmethyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-phenylurea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-2-phenylethan-1-one | Drug Info |
| NET --- SERT | 8-Dimethylcarbamoylmethyl-3-(4-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| NET --- SERT | SID533835 | Drug Info |
| Ftase --- FPTase | [Hydroxy-(5,9,13-trimethyl-tetradeca-4,8,12-trienyl)-phosphinoylmethyl]-phosphonate | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((4-(4-(N-Isopropyl-N-methyl)benzamide)-5-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)methoxy)-2-methylphenoxy)acetic Acid | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(6-((4-hydroxypiperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-methyl-piperidin-3-yl ester | Drug Info |
| PR --- mRNA of AR | rac-3-(3-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-tolylpropan-1-one | Drug Info |
| NPKCdelta --- NPKCtheta | CHEMBL2140607 | Drug Info |
| Ftase --- FPTase | N-(4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzyl)methanesulfonamide | Drug Info |
| PR --- mRNA of AR | 1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-benzene | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-(dimethylamino)piperidin-1-yl)methyl)furan-3-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carboxylic acid isopropylamide | Drug Info |
| PR --- mRNA of AR | 4-[1-(4-Fluorophenyl)-1H-indazol-5-yl]-N-(2-methylpropyl)-3-(trifluoromethyl)benzenesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(3-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| PR --- mRNA of AR | 9-bromo-7-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| CAII --- CAI | (2-{[(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(4-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-thiomorpholinobutyl)phenyl)methanamine | Drug Info |
| PR --- mRNA of AR | 5-Bromo-4-methoxy-2-(2,6,6-trimethyl-4-methylene-cyclohex-2-enylmethyl)-phenol | Drug Info |
| EGFR3 --- HER2 | 4-(3,5-dichloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpiperazin-1-ylsulfonyl)methyl)styryl)nicotinonitrile | Drug Info |
| H3 --- SERT | (6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophen-3-yl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| PR --- mRNA of AR | 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-ol | Drug Info |
| EGFR3 --- HER2 | (R)-N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-((1-(2-methoxyethyl)pyrrolidin-2-yl)ethynyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 5-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-pyridin-2-ylamine | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenoxy-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| PR --- mRNA of AR | 7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dichloro-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylurea | Drug Info |
| PI3K gamma --- PI3K delta | 2-methyl-2-(4-(3-methyl-2-oxo-8-(pyridin-3-ylethynyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| H3 --- SERT | 4-(2-chlorophenyl)-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| Renin --- Cathepsin D | (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-methoxybut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one | Drug Info |
| EGFR3 --- HER2 | 4-(1H-Imidazol-4-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1213118 | Drug Info |
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