Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 2-Bromo-N-[2-((11R,13S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl]-acetamide | Drug Info |
| Met --- VEGFR | 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(2-methoxyphenyl)butanamide | Drug Info |
| PR --- mRNA of AR | Methyl 4-(2-Chloro-4-fluorophenyl)-5-cyano-6-methyl-2-(trifluoromethyl)-1,4-dihydropyridine-3-carboxylate | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| Met --- VEGFR | 2-(4-(7-(2-fluoro-4-(3-oxo-3-(phenylamino)propanamido)phenoxy)thieno[3,2-b]pyridine-2-carbonyl)-1H-imidazol-1-yl)acetic acid | Drug Info |
| Renin --- Cathepsin D | (S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-{(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-[(quinoline-2-carbonyl)-amino]-succinamide | Drug Info |
| Erbeta --- ER | 6-(1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-[4-(4-propyl-phenoxy)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (8R,9S,10R,13S,14S)-10,13-dimethyl-17-(1H-1,2,4-triazol-1-yl)-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-2-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-3-methyl-1-(5-phenyl-1H-imidazol-2-yl)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-propylcarbamoyl-phenyl ester | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-7-(thiophen-2-yl)benzo[d]oxazol-5-ol | Drug Info |
| MMP1 --- MMP3 | 1N-phenyl-2-{1-[1-amino-(1R)-ethylcarboxamido]-4-phenylbutylcarboxamido}-4-methyl-(2S)-pentanamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-methoxycarbonyl-phenyl ester | Drug Info |
| Erbeta --- ER | 1-(4-Fluoro-phenyl)-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butylnonanamide | Drug Info |
| S5AR --- SRD5A2 | 7-((E)-Styryl)-9,10-dihydro-phenanthrene-2-carboxylic acid | Drug Info |
| Erbeta --- ER | 4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[4-(2-methyl-thiazol-4-ylmethyl)-piperazin-1-yl]-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP1 --- MMP9 | Furan-3-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(4'-tert-butyl-4-(trifluoromethyl)biphenyl-2-yl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | [2-(4-{Cyclohexylidene-[4-(2-diisopropylamino-ethoxy)-phenyl]-methyl}-phenoxy)-ethyl]-diisopropyl-amine | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1-isobutyryl-1,4-diazepane-5-carboxamide | Drug Info |
| S5AR --- SRD5A2 | 6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 4-(2-{4-[3-(4-Chloro-phenyl)-propylamino]-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-8-piperazin-1-ylmethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N,N-dibenzyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 7-(3-Fluoro-4-hydroxy-phenyl)-3-hydroxy-naphthalene-1-carbaldehyde | Drug Info |
| MMP13 --- MMP1 | 4-benzylbenzyl(2-(cyclopropylmethyl)-3-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylamino)-3-oxopropyl)phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | ((S)-7-Chloro-4a-methyl-3,4,4a,9-tetrahydro-phenanthren-2-yl)-phosphinic acid | Drug Info |
| Erbeta --- ER | 4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol | Drug Info |
| MMP13 --- MMP1 | 4-(4-Methoxy-phenyl)-5-oxo-pyrrolidine-2-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-phenylsulfanyl)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-3-(4-Hydroxy-phenyl)-4-methyl-2-{4-[2-((S)-3-methyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-chroman-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-pyrazol-1-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-[3-(2-morpholin-4-yl-ethylamino)-propoxy]-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | [4-Bromo-5-hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-yl]-acetonitrile | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-[1,2,4]triazol-4-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| FGFR --- Src | 1-[7-Amino-3-(2,6-dichloro-phenyl)-[1,6]naphthyridin-2-yl]-3-ethyl-urea | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-hydroxyphenyl)-2-(4-((R)-3-methyl-2-(pyrrolidin-1-yl)butoxy)phenyl)-2,3-dihydrobenzo[b][1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP9 | N-hydroxy-2-(4-methoxyphenylsulfonyl)tetradecanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-(dimethylamino)propyl)-N,7,8-trimethyl-4-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Erbeta --- ER | 2-Chloro-2,2-difluoro-1-(6-hydroxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone | Drug Info |
| MMP2 --- MMP1 | 4-Methyl-2-((R)-2-oxo-2-pyridin-2-yl-ethyl)-pentanoic acid [2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID24790162 | Drug Info |
| Erbeta --- Mcl1 | SID14746067 | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-(4-hydroxyphenyl)-2-(N-isopentylnaphthalene-2-sulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-2,4-dichlorobenzamide | Drug Info |
| Ftase --- FPTase | 3-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-morpholin-4-yl-hex-4-ynoic acid | Drug Info |
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