Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | 1-((2R,4aS,5R,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid methyl ester | Drug Info |
| MMP2 --- MMP9 | N-benzyl-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N1-phenyl-N1-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethane-1,2-diamine | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-butyl-piperazin-1-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-Ethyl-1-(4-(6-(piperidin-1-ylmethyl)-pyridin-2-yl)-benzyl)-imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | 3-vFPP | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethynyl)-thiophene-2-sulfonylamino]-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 7-alGGPP | Drug Info |
| MMP2 --- MMP9 | (2R)-[(4-biphenylylsulfonyl) amino]-N-hydroxy-3-phenylpropionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-(2-acetylsulfanyl-ethoxy)-ethyl ester | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)benzo[b]thiophene-2-carboxamide | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(3-methoxyphenylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Src --- VEGFR | (3-Chloro-benzofuran-7-yl)-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-2-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(quinoxaline-2-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1,5-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(3-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-methyl-4-(4-(trifluoromethyl)phenoxy)benzenesulfonamide | Drug Info |
| VEGFR2 --- AuroraA | 7-(1H-pyrrol-2-yl)isoindolin-1-one | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-2-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP9 | (S)-2-(4-acetylpiperazin-1-yl)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- CD135 | N-[4-(3-amino-1-methyl-1H-indazol-4-yl)-phenyl]-N'-(3-methylphenyl)urea | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3,5-Dichloro-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-fluoro-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-amine | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-(3-methyl-3H-imidazol-4-yl)-acetylamino]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-chloro-6-fluorobenzo-[b]-thiophene-2-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6-(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- CDK2 | N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-3,4-dimethoxybenzamide | Drug Info |
| Ftase --- FPTase | 1-[5-Chloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(thiophene-2-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- Cmet | 7-(6,7-dimethoxyquinolin-4-yloxy)-N-ethyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(4-oxo-pentanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP3 --- MMP8 | Carbonic acid ethyl ester 3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl ester | Drug Info |
| VEGFR2 --- Cmet | N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-oxy-pyridin-3-yl ester | Drug Info |
| MMP3 --- MMP8 | Oxo-[2-(4'-trifluoromethyl-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N1-cyclohexyl-N3-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)malonamide | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Cyano-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-isopropylphenyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(4,8-Dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| mTOR --- AKT | N-(6-(2-(4-Methylphenylsulfonamido)pyrimidin-4-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | CHEMBL169186 | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(2-Amino-3-methylsulfanyl-propylamino)-3-methyl-butylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid (FTI1) | Drug Info |
| mTOR --- AKT | N-(6-(5-(4-Methoxyphenylsulfonamido)pyridin-3-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | (5-Fluoro-benzo[1,3]dioxol-4-yl)-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3-Chloro-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
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