Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(5-methoxy-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| Erbeta --- Mcl1 | SID7975783 | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-{1-isobutyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-pyrrolidin-3-yl}-acetamide | Drug Info |
| PR --- mRNA of AR | Methyl 4-(2-Chlorophenyl)-5-cyano-1,4-dihydro-6-methyl-2-propylpyridine-3-carboxylate | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-phenyl-1H-pyrrol-3-yl]-phenyl-methanone | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-o-tolylpiperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| PR --- mRNA of AR | 2,2,4-trimethyl-9-nitro-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Ftase --- FPTase | CHEMBL2365012 | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(2,5-dichlorothiophen-3-ylsulfonyl)-N-hydroxypiperidine-4-carboxamide | Drug Info |
| PR --- mRNA of AR | 1-methyl-5-(2-oxo-5,5-di(thiophen-2-yl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-7-yl)-1H-pyrrole-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-oxo-1-propyl-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP13 | 2-(Biphenyl-4-sulfonylamino)-6-pyrrolidin-1-yl-hex-4-ynoic acid | Drug Info |
| PR --- mRNA of AR | (5bR,9aR)-4-Trifluoromethyl-1,5b,6,7,8,9,9a,10-octahydro-pyrido[2,3-b]carbazol-2-one | Drug Info |
| Ftase --- FPTase | (S)-2-[7-((R)-2-Amino-3-mercapto-propionylamino)-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Hydroxymethyl-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| PR --- mRNA of AR | 1-methyl-5-(4-pivaloylphenyl)-1H-pyrrole-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3''-methoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP13 | (3S)-4-{[4-(but-2-ynylamino)phenyl]sulfonyl}-Nhydroxy-2,2-dimethylthio-morpholine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | 2,2,4-Trimethyl-5-(3-methyl-butyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-ethyl-piperazin-1-yl]-(2,3-dimethyl-phenyl)-methanone | Drug Info |
| MMP2 --- MMP14 | 3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(2-methylbenzoyl)piperidine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | (-)-1,2,3,6-Tetrahydro-3-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-7H-[1,4]oxazino[3,2-g]quinolin-7-one | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| MMP2 --- MMP3 | (R)-N4-hydroxy-N1-((S)-1-((R)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-2-(3-phenylpropyl)succinamide | Drug Info |
| PR --- mRNA of AR | 8,8-Dimethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-((1E,3E)-hepta-1,3-dienyl)-benzonitrile | Drug Info |
| MMP2 --- MMP3 | 2-(4-biphenyl-4-yl-3,6-dihydro-2H-pyridine-1-sulfonyl)-N-hydroxy-acetamide | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(1-methyl-2-oxo-azepan-3-yl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Ftase --- FPTase | 2-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(2',6'-dimethyl-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| S5AR --- SRD5A2 | 17-Diisopropylcarbamoyl-4,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(tert-butylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-10,13-dimethyl-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)-acetic acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-[(3,5-dimethyl-isoxazol-4-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP9 | piperidin-1-ylcarbonylphosphonic acid | Drug Info |
| S5AR --- SRD5A2 | (10S,13S,17S)-17-Diisopropylcarbamoyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-5H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-yl ester | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (10S,13S,17S)-17-Diisopropylcarbamoyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-5H-cyclopenta[a]phenanthrene-3-sulfonic acid | Drug Info |
| Ftase --- FPTase | Cyclic peptide analogue | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-cyclohexylacetyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid [1-(4-chloro-phenyl)-cyclopentyl]-amide | Drug Info |
| Ftase --- FPTase | 2-(2-Phenyl-1H-indol-3-yl)-N,N-bis-pyridin-3-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | (R)-5-(4-chlorophenyl)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholinoethyl)thiophene-2-sulfonamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS,7S)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid naphthalen-1-ylamide | Drug Info |
| Ftase --- FPTase | 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3,5-diethoxybenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| S5AR --- SRD5A2 | ((1S,9aR,11aS)-1-Diethylcarbamoyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridin-5-yl)-acetic acid | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
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