Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| S5AR --- SRD5A2 | N-methyl-N-((4aR,4bS,6aS,7S,9aS,9bR,11aR)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl)formamide | Drug Info |
| Erbeta --- ER | 7-O-n-pentylisoxanthohumol | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1-(2-methoxyacetyl)-1,4-diazepane-5-carboxamide | Drug Info |
| ABL --- Src | 4-(7-(5-amino-2-chlorophenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| Erbeta --- ER | 2-Methyl-4-[6-(methyl-naphthalen-1-ylmethyl-amino)-4-phenyl-pyridin-2-yl]-phenol | Drug Info |
| MMP13 --- MMP14 | 4-{4-[5-Amino-3-(2-ethoxy-ethyl)-2,4,6-trioxo-piperidin-3-yloxy]-phenoxy}-benzamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 3-(6-hydroxybenzo[d]oxazol-2-yl)benzene-1,2-diol | Drug Info |
| MMP13 --- MMP8 | (+/-)-5-(2-amino-2-oxo-ethyl)-4-oxo-N-[(3-oxo-4H-1,4-benzoxazin-6-yl)methyl]-5,6,7,8-tetrahydro-3H-benzothiopheno[2,3-d]pyrimidine-2-carboxamide | Drug Info |
| Lck --- Src | 5-(4-Phenoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Erbeta --- ER | 6-[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylamino)-[1,3,5]triazin-2-ylamino]-5,6,7,8-tetrahydro-naphthalen-2-ol | Drug Info |
| MMP2 --- HER2 | (2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-((R)-3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-tert-butoxy-9H-carbazole | Drug Info |
| Erbeta --- ER | rac-6-bromo-9a-methyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| MMP2 --- MMP1 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-trifluoromethyl-biphenyl-4-yloxymethyl)-ethyl]-N-hydroxy-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)ethanol | Drug Info |
| Erbeta --- Mcl1 | SID48409979 | Drug Info |
| MMP2 --- MMP13 | CHEMBL1940295 | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-N-(3-aminopropyl)-4-(2,5-difluorophenyl)-N-methyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3-Fluoro-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | (S)-N-(2,4-dimethoxybenzyl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-((S)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(pentan-3-ylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(tritylthio)propanamide | Drug Info |
| Ftase --- FPTase | (+)4-(2-{4-[9-bromo-4-chloro-1-methyl-(12R)-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl]hexahydro-1-pyridinyl}-2-oxoethyl)-1-pyridiniumolate | Drug Info |
| MMP2 --- MMP13 | CHEMBL1940316 | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID510722 | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-5H-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | CHEMBL1738748 | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Phenyl-6-methyl-N-(4-nitrophenyl)-4,7-dihydro-2Hpyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((4-(3-chlorophenyl)-2-(2-(methylsulfonyl)ethyl)-5-oxopiperazin-1-yl)methyl)-4-methyl-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| MMP2 --- MMP13 | 3-(5-(benzyloxy)-1H-indol-3-yl)-2-(4-(but-2-ynyloxy)phenylsulfonamido)propanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-((((2R,4aS,5R,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)(ethyl)amino)ethanol | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-2-((S)-2-{2-[Hydroxy-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienyl)-carbamoyl]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyrylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (R)-2-(3-cyclohexylpropyl)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)-N4-hydroxysuccinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-N,N-dimethyl-2H-pyrrole-1(5H)-carboxamide | Drug Info |
| Ftase --- FPTase | 1-{3-(4-Cyano-phenyl)-2-[(3-methyl-3H-imidazol-4-ylmethyl)-amino]-propionyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-methyl-2-{4-[2-methyl-3'-(2-methylamino-ethoxy)-biphenyl-4-yl]-piperidine-1-sulfonyl}-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (5-(3-aminopropyl)-3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)(piperidin-1-yl)methanone | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid propylamide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-6-(4'-fluoro-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-((S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2-hydroxy-3,3-dimethylbutan-1-one | Drug Info |
| Ftase --- FPTase | 3-Benzyl-4-(2-dimethylamino-ethanesulfonyl)-1-(3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-propyl)-N*1*-hydroxy-3-isobutyl-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-methyl-2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[((E)-2-pyrimidin-5-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-6-(3'-Amino-biphenyl-4-yl)-2-butyl-4-((S)-2,2-dimethyl-1-phenylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 4-{5-[(3-Oxo-2-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
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