Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-(2-amino-3-(tritylthio)propanamido)acetic acid | Drug Info |
| Erbeta --- Mcl1 | 3,5,7-trihydroxy-2-(2-hydroxyphenyl)-4H-chromen-4-one | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(4-Benzyloxy-5-ethyl-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-N,N-dimethylbutan-1-amine | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | (R)-2-(N-(2-(dimethylamino)ethyl)naphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-dimethylamino-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-{1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-cyclohexyl}-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-(2,5-difluorophenyl)-5-(thiophen-2-yl)-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(pyridin-4-ylmethylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (2R)-2-Amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-(2-Imidazol-1-yl-vinyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | 1-formyl-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)-2,2-dimethylpropan-1-one | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-phenylethynyl-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)-1-(pyridin-4-ylmethyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-methyl 2-((R)-2-amino-3-(tritylthio)propanamido)-3-methylbutanoate | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | (2R)-N,3-dihydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)butanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-(trifluoromethoxy)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)-2-(methylthio)benzonitrile | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methanesulfinyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-(beta-aminopropionyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-fluoro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(1,1-diphenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-4-yl)-amide | Drug Info |
| MMP2 --- MMP3 | (R)-2-(3-(9H-fluoren-2-yl)propyl)-N1-((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)-N4-hydroxysuccinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(trifluoromethyl)-9H-carbazole | Drug Info |
| Ftase --- FPTase | (S)-3-Phosphono-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoylamino)-propionic acid | Drug Info |
| MMP2 --- MMP3 | (R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-undecylamino]-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-((2R,4aS,5R,10bS)-9-tert-butyl-5-(thiophen-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine | Drug Info |
| Ftase --- FPTase | H-Cys-4-Abz-Met-OH | Drug Info |
| MMP2 --- MMP8 | (cyclopropylamino)carbonylphosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829429 | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(4-hydroxyphenyl)-2-methyl-6-(piperidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | N-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-N-(5-cyano-3''-ethoxy-biphenyl-2-ylmethyl)-acetamide | Drug Info |
| MMP2 --- MMP9 | 5-(biphenyl-4-yl)-5-(4-(4-nitrophenyl)piperazin-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829424 | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-fluorobenzyloxy)phenyl)methan-8-ylsulfonamido)-N,2-dihydroxypropanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-3-carboxy-1,2,3,4-tetrahydro-beta-carboline-3-(N-(2-aminoethyl))formamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-(isobutyl-amide) 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP9 | 5-(4-(Thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Lck --- VEGFR | 5,6-diphenyl-N-(2-(piperazin-1-yl)ethyl)furo[2,3-d]pyrimidin-4-amine | Drug Info |
| Ftase --- FPTase | [(S)-4-[3-(3H-Imidazol-4-yl)-propyl]-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
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