Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| H3 --- SERT | 7-(3-(azetidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Phenoxy-phenylamino)-quinazolin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 4-[2-(5-Ethanesulfonyl-2-methoxy-phenylamino)-oxazol-5-yl]-benzamide | Drug Info |
| H3 --- SERT | 7-(3-morpholinopropoxy)-4-phenyl-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-methoxyquinolin-6-yl)-4-(diethylamino)but-2-enamide | Drug Info |
| PKCA --- NPKC delta | ENZASTAURIN | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| HDAC1 --- Beta PDGFR | N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)terephthalamide | Drug Info |
| EGFR3 --- HER2 | (S)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-indazol-5-ylamino)quinazolin-5-yloxy)propanamide | Drug Info |
| PKCA --- NPKC delta | 4-[2-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-6-hydroxy-benzoyl]-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(2-(4-(3-phenylpyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine | Drug Info |
| HDAC1 --- HD6 | 2-[5-(3,5-Dimethyl-benzylcarbamoyl)-thiophen-2-yl]-2-oxoethylEthyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(4-((2-(methylsulfonyl)ethylamino)methyl)styryl)pyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 3-(4-hydroxy-phenyl)-1-methyl-propyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| HDAC1 --- HD6 | 2-(3-Acetylamino-phenyl)-2-oxoethyl Ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 1-{(E)-3-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-ylcarbamoyl]-allyl}-aziridine-2-carboxylic acid methyl ester | Drug Info |
| PKCA --- NPKC delta | 1-(3-Hydroxypropylamino-3-(2-methylaminopyridin-4-yl)[2,6]-naphthyridine | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| HDAC1 --- HD6 | 2-(5-(5-Amino-pyrid-2-yl)-thieno-2-yl)-2-oxoethyl Ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(3,4,5-trifluorophenoxyacetamido)phenoxy]pyrimidine | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(2-isopropylphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-4-chlorobenzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | 4-(1,4,7-Trioxa-10-aza-cyclododec-10-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-((2-fluoro-4-(trifluoromethyl)benzamido)methyl)-5-methylphenoxy)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-3-biphenyl-4-yl-2-(7-hydroxycarbamoyl-heptanoylamino)-propionic acid methyl ester | Drug Info |
| EGFR3 --- MCSF | (6,7-Dimethoxy-quinazolin-4-yl)-methyl-phenyl-amine; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(1-(3,4-dimethylbenzyl)-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-methylpiperazine-1-carboxamide | Drug Info |
| Erbeta --- ER | 5-(4-bromophenyl)-3-hydroxy-1-(4-hydroxyphenyl)-4-(4-methylbenzoyl)-1H-pyrrol-2(5H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(7-fluoro-3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-2-yl)phenyl)quinoxaline-6-carboxamide | Drug Info |
| Erbeta --- ER | 3-{8-Fluoro-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[b]oxepin-4-yl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-phenoxypropanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide | Drug Info |
| Erbeta --- ER | SID26753216 | Drug Info |
| PPAR gamma --- PPAR delta | SID144212728 | Drug Info |
| HDAC1 --- HDAC2 | 2-Oxo-nonanedioic acid 1-methylamide 9-[(4-pyridin-4-yl-thiazol-2-yl)-amide] | Drug Info |
| Erbeta --- ER | 4-((1R,2R,5R)-5-Hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-benzene-1,2-diol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-5-(3-(3-(4-(4-isopropylphenoxy)-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC4 | (S)-N-cyclopentyl-2-(2-hydroxyacetamido)-7-mercaptoheptanamide | Drug Info |
| Erbeta --- ER | 6-Hydroxy-2-(4-hydroxy-phenyl)-3-methylsulfanyl-inden-1-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(1-(3-(6-benzoyl-1-propylnaphthalen-2-yloxy)propyl)-1H-indol-4-yloxy)-2-methylpropanoic acid | Drug Info |
| HER2 --- CD221 | phenyl 3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenylcarbamate | Drug Info |
| Erbeta --- ER | 4-Bromo-2-(3-fluoro-4-hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(5-methyl-6-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)benzo[b]thiophen-3-yl)acetic acid | Drug Info |
| HER2 --- MMP-2 | CHEMBL565835 | Drug Info |
| Erbeta --- ER | [2-(4-Methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; citrate salt | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(3-methoxypropoxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-2,3-dimethylphenoxy)acetic acid | Drug Info |
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