Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 4-{5-[(3-Oxo-2-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 5-(4-Butylpiperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 3-{[[3-(3,4-Dihydro-2H-quinoline-1-sulfonyl)-phenyl]-(3H-imidazol-4-ylmethyl)-amino]-methyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-2-(benzyl(isopropyl)amino)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-8-fluoro-3-phenyl-3-(3-piperazin-1-yl-propyl)-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-{3-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-benzoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(4-phenylpiperidin-1-yl)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7-(trifluoromethyl)-5H-pyrido[4,3-b]indole | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 29 (FTI-2310) | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-2-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)acetamide | Drug Info |
| Lck --- VEGFR | N-methyl-6-(2-methyl-5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-ylamino)phenyl)quinazolin-2-amine | Drug Info |
| Ftase --- FPTase | 8-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8S,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-carboxylic acid (RPR114235) | Drug Info |
| MMP2 --- MMP9 | (R)-2-{4-[2-(4-Bromo-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| Src --- VEGFR | (R,S)-N-(2-chloro-5-methoxyphenyl)-7-(3-morpholinopropoxy)-5-(tetrahydrofuran-3-yloxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid isopropyl ester | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-5-(1H-benzo[d]imidazol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-ol | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(4-hydroxypiperidin-1-yl)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- CD135 | (Z)-5-{6-[3-(4-Chlorophenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | 4-({[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-piperidine-1-carboximidoyl]-amino}-methyl)-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP9 | (R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylamino)-propionic acid | Drug Info |
| VEGFR2 --- CDK1 | 4-(benzo[d]thiazol-2-yl)-2-(4-(2-hydroxyethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[2-(1H-imidazol-4-yl)-ethyl]-amide} | Drug Info |
| MMP2 --- MMP9 | 2-(1,1-Dioxo-7-phenoxy-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-N-hydroxy-propionamide | Drug Info |
| VEGFR2 --- CDK1 | 3-{5-[4-(4-Morpholin-4-yl-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-3-ylamino}-propan-1-ol | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-6-methyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)benzenesulfonamide | Drug Info |
| VEGFR2 --- Ckit | 1-(2,4-difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-methylphenyl)urea | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Fluoro-biphenyl-4-sulfonyl)-3-hydroxycarbamoyl-1,2,3,4-tetrahydro-isoquinolin-7-yl]-carbamic acid tert-butyl ester | Drug Info |
| VEGFR2 --- Cmet | 5-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| MMP3 --- MMP8 | {(S)-1-[3-Hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| VEGFR2 --- Cmet | 1-tert-butyl-N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 16-ethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP3 --- MMP8 | 2-(4-Benzoyl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-(2-(dimethylamino)ethyl)-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methoxy-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP9 --- MMP8 | {(R)-3-[(S)-2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbamoyl]-5-methyl-hexanoylaminooxy}-acetic acid methyl ester | Drug Info |
| VEGFR2 --- CSrc | 2-((4-((3-(dimethylamino)propyl)oxy)-phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-4-yl)-amide | Drug Info |
| mTOR --- AKT | N-(6-(5-(3-tert-Butylphenylsulfonamido)-6-chloropyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-1-tert-butyl-5-((4-methylpiperazin-1-yl)methyl)-1H-pyrazole-3-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(3,4-dimethoxyphenyl)urea | Drug Info |
| VEGFR2 --- CSrc | 2,6-dimethylphenyl-2,4-bis(methyloxy)phenyl(2-((4-((3-(1-piperidinyl)propyl)oxy)phenyl)amino)-4-pyrimidinyl)carbamate | Drug Info |
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