Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| H3 --- SERT | N,N-diethyl-3-(6-methyl-8-phenyl-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-imidazole-2-carboxamide | Drug Info |
| H3 --- SERT | 3-(4-methoxyphenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 4-[(2-Methoxy-ethyl)-methyl-amino]-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-6-fluoro-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | (2-(3,4-dichlorophenoxy)-5-(4-(4-fluoropiperidin-1-yl)but-1-ynyl)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 5-(bis(2,5-dihydroxybenzyl)amino)-2-hydroxybenzoic acid | Drug Info |
| PI3K gamma --- PI3K delta | 2-(4-(2-methyl-8-(2-(pyridin-3-yl)ethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-1-methyl-N-(3-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxamide | Drug Info |
| HDAC --- VEGFR | N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2,5-dicarboxamide | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-p-tolylacrylate | Drug Info |
| PKCA --- NPKC delta | 4-(2-Acetoxymethoxycarbonyl-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | GW632046X | Drug Info |
| HDAC1 --- HD6 | 2-(N-Acetamido)-ethyl 2-(4-methoxyphenyl)-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-(2-hydroxy-6-methanesulfonylamino-benzoyl)-benzoic acid (R)-2-((S)-4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-(4-(chlorodifluoromethoxy)phenyl)benzamide | Drug Info |
| HDAC1 --- HD6 | N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide | Drug Info |
| EGFR3 --- HER2 | 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carbohydrazide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-piperidin-4-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| HDAC1 --- HD6 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(4-((cyclopropylamino)methyl)styryl)-6-methylpyrimidin-4-amine | Drug Info |
| PPAR gamma --- 5LOX | (R)-2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-3-chlorobenzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Chloro-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-bis(4-bromophenyl)allyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(4-phenylthiazol-2-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- MCSF | (4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-methyl-amine; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-4-ethoxy-2-fluoro-benzyl}-butyric acid | Drug Info |
| HDAC1 --- HDAC2 | 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one | Drug Info |
| Erbeta --- ER | (4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-(4-methoxy-phenyl)-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-((1-methyl-5-(4-(pyrrolidin-1-yl)phenyl)-1H-pyrazole-3-carboxamido)methyl)phenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-(Biphenyl-4-sulfonyl)-2-oxo-octanoic acid methylamide | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-phenyl-3,4-dihydro-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-6-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(((3-(benzo[d][1,3]dioxol-5-yloxy)propyl)(benzo[d]oxazol-2-yl)amino)methyl)phenoxy)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-amino-biphenyl-3-yl)-4-[(3,4-dimethoxy-phenylamino)-methyl]-benzamide | Drug Info |
| Erbeta --- ER | 4-{(E)-1-[4-(2-Diethylamino-ethoxy)-phenyl]-hexadec-1-enyl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-ethoxy-3-(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-1H-indol-4-yl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)morpholine-4-carboxamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(2,6-Dimethyl-piperidin-1-yl)-ethoxy]-phenyl}-3-(3-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(1-(5-chloro-3-methylbenzo[b]thiophene-2-carboxamido)ethyl)-5-fluorophenoxy)-2-ethylphenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) | Drug Info |
| Erbeta --- ER | 17alpha-[2-Cyano-2-(ethoxycarbonyl)-1,3-dihydro-2H-inden-5-yl]-estradiol | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(4-ethyl-2-(thiazol-4-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| HER2 --- CD221 | 1-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-3-phenylurea | Drug Info |
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