Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| ABL --- Src | 4-(2,4-Dichloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-{4-[2-((R)-2-methyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-{4-[4-(3,4-dihydro-2H-[1,2,4]triazol-3-yl)-phenoxy]-phenoxy}-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| FGFR --- Src | 1-tert-Butyl-3-{6-(2,6-dichloro-phenyl)-2-[(3-dimethylamino-propyl)-methyl-amino]-pyrido[2,3-d]pyrimidin-7-yl}-urea | Drug Info |
| Erbeta --- ER | 6-(1,1-dioxo-1,2,3,6-tetrahydro-1lambda*6*-thiopyran-4-yl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol | Drug Info |
| MMP13 --- MMP9 | 2-{[4-(2-Cyano-ethyl)-benzenesulfonyl]-methyl-amino}-N-hydroxy-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)acetonitrile | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-7-(prop-1-enyl)benzo[d]oxazol-5-ol | Drug Info |
| MMP2 --- MMP1 | N-[1-(4-Furan-2-yl-phenoxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-N-hydroxy-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (2S)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one | Drug Info |
| Erbeta --- Mcl1 | SID14742318 | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-ethynyl-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-methoxyphenyl)diphenylmethylthio)propanoic acid | Drug Info |
| FGFR --- PDGFR | 5-Methoxy-1-thiophen-3-yl-1H-benzoimidazole | Drug Info |
| MMP2 --- MMP13 | (R)-4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(2-(hydroxymethyl)pyrrolidin-1-ylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-1-(methylsulfonyl)-5-phenyl-4,5-dihydro-1H-pyrazole | Drug Info |
| Ftase --- FPTase | (2S)-2-(5-((1H-imidazol-4-yl)methylamino)-2'-methylbiphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2,4-dimethylphenyl)piperazin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3'-Hydroxyphenyl)-3-methyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | (4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a]quinolin-7-yl)(1-methyl-1H-imidazol-5-yl)methanamine | Drug Info |
| MMP2 --- MMP13 | N-allyl-1-(4-(4-(hydroxycarbamoyl)tetrahydro-2H-pyran-4-ylsulfonyl)phenyl)-N-methylpiperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-(4-(benzylamino)butyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-1-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-3-mercapto-propan-1-one | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylquinoline-6-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP13 | 2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sulfonylamino]-5-phenyl-pent-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-9-tert-butyl-5-(pyridin-3-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-yl)-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-methoxy-2-methylphenyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-benzhydryl 2-amino-3-(tritylthio)propanoate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(5-oxo-hexanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| MMP2 --- MMP3 | N-hydroxy-2-[4-(2-methyl-3'-trifluoromethoxy-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-amine | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP3 | [(S)-2-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-benzyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclopropylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| MMP2 --- MMP3 | Methyl-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 6-Ethyl-1-(3-hydroxyphenyl)-2-propyl-2,3,4,9-tetrahydro-1H-beta-carboline | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1H-quinolin-2-one | Drug Info |
| MMP2 --- MMP3 | (R)-3-{(S)-2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-6-p-tolyl-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-5-methyl-2-(thiophene-2-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(3,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorophenoxy)phenyl)methan-2-ylsulfonamido)-2-(cis-2,6-dimethylmorpholino)-N-hydroxypropanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-chloro-1-cyclohexyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-5,7-Dichloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | 2-[7-(4,5-Dimethyl-thiazol-2-ylmethoxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-3-methyl-butyramide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 6-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinolin-2(1H)-one | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
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