Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Renin --- Cathepsin D | N-[2-(5-Amino-thiophen-3-yl)-1-(1-cyclohexylmethyl-2,4-dihydroxy-hexylcarbamoyl)-ethyl]-2-(morpholine-4-sulfonylamino)-3-phenyl-propionamide | Drug Info |
| Erbeta --- ER | 7-Isopropenyl-4-methyl-9-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-ol | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Fluoro-4H-thieno[3,2-b]indole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid (1-cyclohexylmethyl-2,4-dihydroxy-hexyl)-amide | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-(4-m-tolyloxy-butyl)-succinamide | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-10,13-Dimethyl-3-nitro-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid diisopropylamide | Drug Info |
| Erbeta --- ER | 2-Ethyl-3-(4-hydroxy-phenyl)-2H-benzo[1,4]oxazine-5,7-diol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-[4-(4-methoxy-phenoxy)-butyl]-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-tert-butyl-phenyl)-cyclohexyl]-amide | Drug Info |
| Erbeta --- ER | CHEMBL1190175 | Drug Info |
| MMP1 --- MMP8 | (R)-5-(4-Acetyl-piperazin-1-yl)-2-[benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benzenesulfonyl)-amino]-5-oxo-pentanoic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | N-phenyl-N-((4aR,4bS,6aS,7S,9aS,9bR,11aR)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl)benzamide | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-7-(5-(piperidin-1-yl)pentyloxy)-1H-indol-3-yl)acetamide | Drug Info |
| MMP1 --- MMP9 | (3R,6S)-3-Mercaptomethyl-1-(4-methoxy-benzyl)-6-(4-nitro-benzyl)-piperazine-2,5-dione | Drug Info |
| S5AR --- SRD5A2 | 1-(Adamantane-2-carbonyl)-9a,11a-dimethyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridin-7-one | Drug Info |
| Erbeta --- ER | 1-Bromo-6-(3-hydroxyphenyl)-2-naphthol | Drug Info |
| MMP13 --- MMP1 | 1-benzyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1,4-diazepane-5-carboxamide | Drug Info |
| S5AR --- SRD5A2 | 2-Chloro-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-benzenesulfonyl]-3-methyl-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | sodium-3,3-diisopropyltriaz-1-en-1-olate 2-oxide | Drug Info |
| Erbeta --- ER | 5-[4-(2-azepan-1-yl-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromene-2,8-diol | Drug Info |
| MMP13 --- MMP1 | (R)-3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetrahydro-furan-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-1-(2,4,6-triisopropylbenzoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| Erbeta --- ER | 4-chloro-6-(6-hydroxybenzo[d]isoxazol-3-yl)benzene-1,3-diol | Drug Info |
| MMP13 --- MMP1 | (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-(1-iso-butyl-piperidin-4-yl)-acetic Acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid diethylamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(3-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | {2-[4-(4-But-2-ynyloxy-benzenesulfonyl)-3-hydroxycarbamoyl-[1,4]diazepan-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| ABL --- Src | 4-(4-Bromo-2-chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 3,8-dihydroxy-4,7,10-trimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| MMP13 --- MMP14 | N-((2S,4S)-1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)pentan-2-yl)-N-hydroxyformamide | Drug Info |
| ABL --- Src | 4-(2,4-Dichloro-phenylamino)-6,7-diethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2-(3-chloro-4-hydroxyphenyl)-6-hydroxybenzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| MMP13 --- MMP9 | 2-(4-but-2-ynyloxybenzenelsulfonyl)octanoic acid hydroxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Erbeta --- ER | 7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol | Drug Info |
| MMP2 --- HER2 | (3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phenylpiperazine-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1188100 | Drug Info |
| Erbeta --- Mcl1 | 3-amino-N-(furan-2-ylmethyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-[4-(4-trifluoromethyl-benzyloxy)-piperidine-1-sulfonyl]-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(4-tert-butylphenyl)pyridine | Drug Info |
| FGFR --- PDGFR | 5-(3-Morpholin-4-yl-propoxy)-1-phenyl-1H-benzoimidazole | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(6-hydroxy-N-isopentylnaphthalene-2-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-naphthalen-1-ylmethyl-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | 3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(4-methylbenzoyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[5-(3-chlorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-isoindole-1,3-dione | Drug Info |
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