Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | 11-(3',5'-Dichloro-biphenyl-4-ylmethyl)-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide] | Drug Info |
| Ftase --- FPTase | 5-((2-cyanobenzyloxy)(1-methyl-1H-imidazol-5-yl)methyl)-2'-methylbiphenyl-2-carbonitrile | Drug Info |
| ABL --- Src | 6,7-Bis-(2-methoxy-ethoxy)-4-(3,4,5-trimethoxy-phenylamino)-quinoline-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxoazepan-3-yl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-oxo-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(isobutylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | methyl 4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-ylamino)-6-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate | Drug Info |
| MMP2 --- MMP9 | 3-hydroxy-1-((5-(4-methoxyphenoxy)thiophen-2-ylsulfonyl)methyl)pyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | 3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-7-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-2-(p-aminobenzoyl)-6-chloro-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| MMP2 --- MMP9 | 5-(4-(Cyclopropylmethyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-acetyl-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methyl-N-(3-(methylsulfonamido)propyl)benzamide | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorophenoxy)phenyl)methan-15-ylsulfonamido)-N,2-dihydroxypropanamide | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-3-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | Drug Info |
| MMP3 --- MMP8 | N-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide | Drug Info |
| Ftase --- FPTase | 17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-benzyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Chloro-biphenyl-4-sulfonyl)-7-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | SID103905591 | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N,6-triethyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | Drug Info |
| MMP3 --- MMP8 | 5-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-4-methoxy-thiophene-3-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-3-Methyl-2-{2-[1-(4-nitro-benzyl)-1H-imidazol-4-yl]-acetylamino}-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N-ethyl-5-(2-hydroxyethyl)-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]oxazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-4-methylsulfanyl-2-({2'-methyl-5-[5-(4-trifluoromethyl-phenyl)-furan-2-ylmethoxymethyl]-biphenyl-2-carbonyl}-amino)-butyrate | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(S)-5-[3-(4-acetyl-piperazin-1-yl)-propyl]-3-(2,5-difluoro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone | Drug Info |
| mTOR --- AKT | N-(5-(Benzo[d]thiazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[(3R,3aR)-3-(3-dimethylamino-propyl)-8-fluoro-3-phenyl-3a,4-dihydro-3H-5-oxa-1,9b-diaza-cyclopenta[a]naphthalen-2-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(1,4'-bipiperidine-1'-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-phenyl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-cyanophenyl)urea | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(2-nitro-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2-chloro-10H-phenothiazin-10-yl)-3-(phenethylamino)propan-2-ol | Drug Info |
| mTOR --- PI3K gamma | N-(2-(Dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide Hydrochloride | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-cyanobenzamide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-pyridin-3-ylurea | Drug Info |
| Ftase --- FPTase | 3-benzo[1,3]dioxol-5-yl-4-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-N,5-dimethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| NET --- SERT | CHEMBL1199321 | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-4-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-3,3-dimethylbutan-1-one | Drug Info |
| NET --- SERT | 3N-{3-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarboxamido]propyl}-4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxamide | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methyl)quinoline-2-carboxamide | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.