Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylmethoxy)picolinamide | Drug Info |
| Erbeta --- ER | SID14726689 | Drug Info |
| VEGFR2 --- TEK | propyl N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}carbamate | Drug Info |
| JNK1 --- JNK3 | 2-(2-(3-methoxyphenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| VEGFR2 --- TEK | 7-acetyl-19-methyl-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| JNK1 --- JNK3 | 4-(3-fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| Erbeta --- ER | 10-ethyl-3-hydroxy-8-methoxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea | Drug Info |
| MEP --- Cathepsin B | Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone | Drug Info |
| Erbeta --- ER | CHEMBL242818 | Drug Info |
| VEGFR2 --- TEK | (S)-N-(2-(3-aminopiperidin-1-yl)-5-(trifluoromethyl)phenyl)-5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluorobenzamide | Drug Info |
| MEP --- Cathepsin B | 6-(3-(furan-2-yl)benzylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | Drug Info |
| Erbeta --- ER | (E)-2-chloro-3,4'-dihydroxybiphenyl-4-carbaldehyde oxime | Drug Info |
| VEGFR2 --- TEK | N-(2-chloro-5-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-3-isopropylbenzamide | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-naphthalen-1-yl-ureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| MEP --- Cathepsin B | 2-((3,5-dichlorophenyl)(thiophen-2-yl)methylene)hydrazinecarbothioamide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-ethylphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MEP --- Cathepsin B | 4'-Isoxazol-5-yl-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| Erbeta --- ER | 2-(4-(ethylsulfonyl)phenyl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)benzo[b]thiophen-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-Bromo-4-chloro-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| MEP --- Cathepsin B | (E)-methyl4-(2-((R,Z)-3-((4-chloro-2-(trifluoromethyl)phenylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate | Drug Info |
| Erbeta --- ER | (R)-5-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(3-(4-methylpiperazin-1-yl)propyl)-3-(5-(thiophen-3-yl)pyridin-3-yl)-1H-indole | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| Erbeta --- ER | (3aR,4S,9bS)-4-phenyl-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-phenoxyphenyl)benzamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(thiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Erbeta --- ER | 7-Isopropenyl-4-methyl-9-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-ol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Fluoro-4H-thieno[3,2-b]indole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-4-methyl-benzenesulfonamide | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-(4-m-tolyloxy-butyl)-succinamide | Drug Info |
| Erbeta --- ER | 2-Ethyl-3-(4-hydroxy-phenyl)-2H-benzo[1,4]oxazine-5,7-diol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-[4-(4-methoxy-phenoxy)-butyl]-succinamide | Drug Info |
| Erbeta --- ER | CHEMBL1190175 | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-tert-butylphenyl)-3-methyl-5-(pyridin-4-ylmethylamino)isoxazole-4-carboxamide | Drug Info |
| MMP1 --- MMP8 | (R)-5-(4-Acetyl-piperazin-1-yl)-2-[benzo[1,3]dioxol-5-ylmethyl-(4-methoxy-benzenesulfonyl)-amino]-5-oxo-pentanoic acid hydroxyamide | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-7-(5-(piperidin-1-yl)pentyloxy)-1H-indol-3-yl)acetamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| MMP1 --- MMP9 | (3R,6S)-3-Mercaptomethyl-1-(4-methoxy-benzyl)-6-(4-nitro-benzyl)-piperazine-2,5-dione | Drug Info |
| Erbeta --- ER | 1-Bromo-6-(3-hydroxyphenyl)-2-naphthol | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| MMP13 --- MMP1 | 1-benzyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1,4-diazepane-5-carboxamide | Drug Info |
| Erbeta --- ER | 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-benzenesulfonyl]-3-methyl-piperazine-2-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 5-[4-(2-azepan-1-yl-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromene-2,8-diol | Drug Info |
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