Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP3 | 3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic acid (4'-cyano-biphenyl-4-ylmethyl)-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-methoxyphenylamino)-N-methyl-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-benzenesulfonamide | Drug Info |
| MMP2 --- MMP3 | [4-(3-Ethyl-ureido)-butyl]-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-4-[2-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-piperazine | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-trifluoromethoxy-benzyl ester | Drug Info |
| MMP2 --- MMP9 | N-[2-(1-Hydroxycarbamoyl-ethyl)-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda*6*-benzo[f][1,2,5]thiadiazepin-7-yl]-3,5-dimethyl-benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 8-ethyl-4-(3-hydroxyphenyl)-N,N-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxamide | Drug Info |
| Ftase --- FPTase | (E)-3-Carboxy-2-(16-sulfooxy-hexadecyl)-pent-2-enedioic acid | Drug Info |
| MMP2 --- MMP9 | (S)-2-(1,1-dioxo-1lambda*6*-thiomorpholin-4-yl)-N-hydroxy-3-{methanesulfonyl-[4-(4-trifluoromethyl-phenoxy)-phenyl]-amino}-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3'-amino-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | 3-(4-(5-fluoro-1H-benzo[d]imidazol-2-yl)phenylsulfonyl)-1-hydroxyazepan-2-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(3-hydroxyphenyl)-2-(3-aminobutyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinolin-3-ylmethyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-N,2-dihydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-ethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanamine trihydrochloride | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-cyclohexylmethyl-benzenesulfonamide | Drug Info |
| MMP2 --- MMP9 | 2-[1,1-Dioxo-7-(4-trifluoromethyl-phenoxy)-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| Lck --- VEGFR | 1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(3-Chloro-4-cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-phenyl-propionic acid | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-7-methoxy-5-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)-2-(methylsulfonyl)benzonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-N-hydroxy-3-(quinolin-8-ylsulfonyl)thiazolidine-4-carboxamide | Drug Info |
| VEGFR2 --- AuroraA | 4-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline | Drug Info |
| Ftase --- FPTase | 4'-(3-Mercapto-propionylamino)-[1,1';2',1'']terphenyl-3-carboxylic acid 37 (FTI-2317) | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[5-(4-nitro-phenylethynyl)-thiophene-2-sulfonylamino]-propionic acid | Drug Info |
| VEGFR2 --- CD135 | 1-(1-chloro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-8-yl)-3-(4-chloro-3-trifluoromethyl-phenyl)-urea | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Amino-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperidin-1-ylsulfonyl)methyl)tetrahydro-2H-pyran-4-yl)-N-hydroxyformamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(3-morpholino-3-oxopropyl)phenylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | Acetic acid 2-acetoxy-6-(3-acetoxy-2,5-diformyl-benzoyl)-phenyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-2-(cis-2,6-dimethylmorpholino)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- CDK1 | 5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-N-[2-(dimethylamino)ethyl]pyridine-3-carboxamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-chloro-3-fluoro-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-iodo-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR2 --- Ckit | 1-(2-chlorophenyl)-3-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)urea | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide | Drug Info |
| MMP3 --- MMP8 | Oxo-[2-((E)-2-phenyl-ethenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Chloro-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | 7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(thiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| MMP3 --- MMP8 | 2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-chloro-6-methoxypyridin-2-yl)-5-isopropoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 6-[(3'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP9 --- MMP8 | N-Hydroxy-N'-[(S)-3-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-butyl]-oxalamide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-(4-(diethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-m-tolylbenzamide | Drug Info |
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