Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | (20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-18,20-ethano-6,10:12,1 6-dimetheno-16H-imidazo-[3,4-h][1,8,11,14]oxatriazacycloeicosine-9-carbonitrile | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-4-(1H-indol-3-yl)-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)pyrimidin-2-amine | Drug Info |
| MMP3 --- MMP8 | 2-(4-Benzenesulfonyl-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-4-Methylsulfanyl-2-{2-[((S)-3-methyl-2-{2-[3-((2E,7E)-3,8,12-trimethyl-trideca-2,7,11-trienyl)-3H-imidazol-4-yl]-acetylamino}-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-butyric acid | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid amide | Drug Info |
| MMP8 --- MMP14 | ((R)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-3-phenyl-propyl]-phosphinic acid | Drug Info |
| Ftase --- FPTase | 1-(3H-Imidazol-4-ylmethyl)-4-(naphthalene-1-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(4-((2-(dimethylamino)ethyl)(methyl)carbamoyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| mTOR --- AKT | 2-amino-4-methyl-6-(1H-pyrazol-3-yl)-8-(tetrahydro-2H-pyran-4-yl)pteridin-7(8H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-methyl]-3-benzyloxy-tetrahydro-pyran-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(3-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-2-yl-1H-pyrrol-3-yl]-p-tolyl-methanone | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-(2-fluorophenyl)cyclopropane-1,1-dicarboxamide | Drug Info |
| mTOR --- PI3K gamma | methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| Ftase --- FPTase | (S)-4-Methylsulfanyl-2-({5-[(1-naphthalen-1-ylmethyl-1H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-butyric acid | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-bromophenyl)-4-methylbenzamide | Drug Info |
| mTOR --- PI3K gamma | N-Ethyl-4-({[4-(3-ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)benzamide | Drug Info |
| Ftase --- FPTase | 1-{2-[Benzyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-(2-cyanoethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| mTOR --- PI3K gamma | 3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol | Drug Info |
| Ftase --- FPTase | 4-[(5,3'-dichloro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| VEGFR2 --- CSrc | CHEMBL426161 | Drug Info |
| mTOR --- PI3K gamma | tert-butyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | Drug Info |
| Ftase --- FPTase | 4-{5-[(S)-4-(3-Chloro-phenyl)-2-methyl-5-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| VEGFR2 --- CSrc | (R,S)-N-(2-chloro-5-methoxyphenyl)-7-(3-morpholinopropoxy)-5-(tetrahydrofuran-3-yloxy)quinazolin-4-amine | Drug Info |
| NET --- SERT | Amiflamine | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid 24 (FTI-2312) | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methylbenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide | Drug Info |
| NET --- SERT | 1-[3-(5-Ethyl-6-methoxy-naphthalen-2-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-propan-1-one | Drug Info |
| Ftase --- FPTase | 2-[3-(1-Acetyl-3-ethyl-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| VEGFR2 --- FGFR1 | 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[4-morpholin-4-yl-3-(trifluoromethyl)phenyl]urea | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-phenethylnicotinonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-4-Chloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| VEGFR2 --- TEK | rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-methoxypiperazin-1-yl)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-tert-butylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(6-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-[(5-chloro-3'-ethoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(ethoxyimino)-2-methylpropyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(Isopropylsulfonyl)piperazin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide | Drug Info |
| VEGFR2 --- TEK | 1-[4-(dimethylamino)phenyl]-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(Aminomethyl)piperidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotino | Drug Info |
| GSK --- VEGFR | Pyrrolidine-1-carboxylic acid [6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-yl]-amide | Drug Info |
| VEGFR2 --- TEK | N-(3-(2-aminoquinazolin-6-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-(5-phenylthiazol-2-ylthio)phenylamino)-3-cyano-7-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(2-((4-methylpiperazin-1-yl)methyl)styryl)nicotinonitrile | Drug Info |
| H3 --- SERT | 7-(3-(4-cyclopropylpiperazin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
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