Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HDAC1 --- HD6 | (R)-3-(3-(4-benzyl-1-(1-ethylpiperidin-3-yl)-5-methyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-7-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| PKCA --- NPKC delta | 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-quinolin-3-yl-1H-indol-3-yl)-pyrrole-2,5-dione | Drug Info |
| HDAC1 --- HD6 | 3-(3-(1-(2-(dimethylamino)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | 4-(3-bromophenylamino)-6,7-bis(2-methoxyethoxy)quinoline-3-carbonitrile | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(p-tolyloxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| HDAC1 --- HD6 | 3-(3-(2,4-dimethyl-1-phenethyl-1H-imidazol-5-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | 2-(3-Phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(1-(3-(6-benzoyl-1-propylnaphthalen-2-yloxy)propyl)-1H-indol-6-yloxy)-2-methylpropanoic acid | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-{4-[(quinoline-3-carbonyl)-amino]-phenyl}-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- MCSF | (3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-methyl-amine; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)pentanoic acid | Drug Info |
| HDAC1 --- HDAC2 | pyridin-3-ylmethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate | Drug Info |
| Erbeta --- ER | 5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,11-dihydro-chromeno[4,3-c]chromene-2,8-diol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-{[[1,3]dioxolo[4',5':4,5]benzo[1,2-d]oxazol-6-yl-(3-phenoxy-propyl)-amino]-methyl}-phenoxy)-butyric acid | Drug Info |
| HDAC1 --- HDAC2 | N-hydroxy-7-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide | Drug Info |
| Erbeta --- ER | 17alpha-(1,3-Dihydro-2-tosyl-2H-indol-5-yl)-estradiol | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((R)-3-(4-ethyl-2-(pyridin-3-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-hydroxy-7-(2-(4-(trifluoromethoxy)phenyl)oxazol-5-yl)heptanamide | Drug Info |
| Erbeta --- ER | (S)-methyl 9a-butyl-7-oxo-3,7,8,9,9a,10-hexahydroindeno[2,1-e]indazole-6-carboxylate | Drug Info |
| PPAR gamma --- PPAR delta | 4'-butoxy-3'-((2-fluoro-4-(trifluoromethyl)benzamido)methyl)biphenyl-2-carboxylic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-aminophenyl)-4-(1,3-dioxo-1,3-bis(phenylamino)propan-2-yl)benzamide | Drug Info |
| Erbeta --- ER | 6-(4-Methanesulfonyl-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol; hydrochloride | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(4-(3-(2-chlorophenoxy)propoxy)benzyl)-2-methylbutanoic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-N-(1-(cyclopentylamino)-7-mercapto-1-oxoheptan-2-yl)-benzamide | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-4,4-dioxo-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3,4-dihydro-2H-4lambda*6*-benzo[1,4]oxathiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[3-(2-phenyl-7-propyl-1H-indol-6-yloxy)propoxy]-indol-1-yl}ethanoic acid | Drug Info |
| HER2 --- CD221 | 1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-phenethyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| Erbeta --- ER | 2-(3-chloro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{6-[3-(7-propyl-3-trifluoromethylbenzo[d]isoxazol-6-yloxy)propoxy]-1H-indol-1-yl}ethanoic acid | Drug Info |
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-((R)-3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | (R)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| PPAR gamma --- PPAR delta | methyl 2-(4-(3-(6-acetyl-5-hydroxy-4-propylpyridin-3-yloxy)propoxy)phenoxy)acetate | Drug Info |
| JNK1 --- JNK3 | trans-4-(4-(3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)cyclohexanol | Drug Info |
| Erbeta --- ER | 2-Phenyl-benzo[b]thiophen-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-4-(trifluoromethoxy)biphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-(trifluoromethyl)quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | (2S,3R)-7-Hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one oxime | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(2-propyl-4-(tetrahydro-2H-pyran-4-yl)phenoxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | 4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-dip-tolylallyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| Erbeta --- ER | 9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-tetrahydro-3H-fluoren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(4-(3-(1-(5-chloro-1,3-dimethyl-1H-indole-2-carboxamido)ethyl)-5-fluorophenoxy)-2-ethylphenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | methyl 3-(2-(isoquinolin-5-yl)acetamido)thiophene-2-carboxylate | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyanophenyl)-1-isopropyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| Erbeta --- ER | 4-{[4-(4-Methyl-piperazin-1-yl)-6-(3-phenyl-propylamino)-[1,3,5]triazin-2-ylamino]-methyl}-phenol | Drug Info |
| PPAR gamma --- PPAR delta | {4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenoxy}-acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-cyano-3-(thiazol-4-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-phenylpropan-1-one | Drug Info |
| Erbeta --- ER | (S)-(-)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5H-6-oxachrysen-2-ol hydrochloride | Drug Info |
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