Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-methyl-2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| MMP2 --- MMP3 | (R)-N4-hydroxy-N1-((S)-1-((R)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-((1E,3E)-hepta-1,3-dienyl)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP2 --- MMP3 | 2-(4-biphenyl-4-yl-3,6-dihydro-2H-pyridine-1-sulfonyl)-N-hydroxy-acetamide | Drug Info |
| Ftase --- FPTase | 2-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID22404065 | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(2',6'-dimethyl-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-2-methylbenzamide | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(tert-butylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-[(3,5-dimethyl-isoxazol-4-ylmethyl)-amide] | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(3-hydroxyphenyl)-2-(3-aminopropyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| MMP2 --- MMP9 | piperidin-1-ylcarbonylphosphonic acid | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-yl ester | Drug Info |
| HER2 --- VEGFR | 3-[1-(4-Isopropyl-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | Cyclic peptide analogue | Drug Info |
| Src --- VEGFR | CHEMBL198701 | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-cyclohexylacetyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 2-(2-Phenyl-1H-indol-3-yl)-N,N-bis-pyridin-3-ylmethyl-acetamide | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2-yl)quinolin-2(1H)-one | Drug Info |
| MMP2 --- MMP9 | (R)-5-(4-chlorophenyl)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholinoethyl)thiophene-2-sulfonamide | Drug Info |
| Ftase --- FPTase | 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- Beta PDGFR | CHEMBL1269858 | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3,5-diethoxybenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| VEGFR2 --- CDK1 | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butan-2-yl)formamide | Drug Info |
| Ftase --- FPTase | 2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-morpholinoethyl)phenyl)pyrimidin-2-amine | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-methyl-4-(4-(trifluoromethoxy)phenoxy)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4-chloro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(3-fluoro-4-methylphenyl)urea | Drug Info |
| MMP2 --- MMP9 | 1-hydroxy-3-(4-(4-methoxyphenoxy)phenylsulfonyl)azepan-2-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-3-yl-ethanone | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-5-methyl-3-oxo-1-(2-oxopropyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| Ftase --- FPTase | N-Furan-3-ylmethyl-N-isopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| VEGFR2 --- Cmet | 4-(4-(6-benzylpyridazin-3-yl)-2-fluorophenoxy)-6,7-dimethoxyquinoline | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenylazo-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | (2-Benzylamino-phenyl)-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1,3,4-thiadiazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylmethyl-amide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| VEGFR2 --- CSrc | CHEMBL216105 | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-(2-methoxyethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide | Drug Info |
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