Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- FGFR1 | 1-tert-Butyl-3-[3-(3,5-dimethoxy-phenyl)-7-(5-phenoxy-pentylamino)-[1,6]naphthyridin-2-yl]-urea | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-(4-nitrophenoxy)-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-(trifluoromethoxy)quinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N-(2-(dimethylamino)ethyl)-N-methylacrylamide | Drug Info |
| VEGFR2 --- TEK | methyl N-(6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy) benzoxazol-2-yl)carbamate | Drug Info |
| H3 --- SERT | 1-(4-ethylphenyl)-3-methyl-6-(4-(4-(1-phenylvinyl)cyclohexyl)butyl)-1,2,3,4-tetrahydronaphthalene | Drug Info |
| EGFR3 --- HER2 | 1-(5-Bromo-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- TEK | 3-{10-carboximidoyl-5-oxo-14-propyl-4,14-diazapentacyclo[11.7.0.0^{2,6}.0^{7,12}.0^{15,20}]icosa-1(13),2(6),7(12),9,15,17,19-heptaen-18-yl}-1-(4-methylphenyl)urea | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(1-benzenesulfonyl-1H-indol-5-ylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- TEK | rac-9-cyclohexyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| H3 --- SERT | (5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(4-benzylamino-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- TEK | rac-9-(2-(diethylamino)ethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| H3 --- SERT | 7-(3-(3,3-difluoropyrrolidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | [4-(3-fluoro-benzyloxy)-3-trifluoromethyl-phenyl]-{6-[5-(1-oxo-1lambda*4*-thiomorpholin-4-ylmethyl)-furan-2-yl]-quinazolin-4-yl}-amine | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-imidazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- TEK | (E/Z)-4-(2-(1-benzyl-4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| HDAC --- VEGFR | N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)pyridine-2,5-dicarboxamide | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dichloro-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylthiourea | Drug Info |
| PKCA --- NPKC delta | N1-(3-(pyridin-4-yl)-2,6-naphthyridin-1-yl)ethane-1,2-diamine | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(2-(quinolin-3-yl)ethynyl)-N-(3-(trifluoromethyl)-phenyl)benzamide | Drug Info |
| HDAC1 --- HD6 | Ethyl 2-oxo-2-[3-(2-phenoxy-ethylcarbamoyl)-phenyl]-ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2,4-difluoro-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Ethoxycarbonyl-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| VEGFR2 --- TEK | 3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(thiophen-2-yl)urea | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-(4-bromophenyl)acrylate | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (2R,3R)-3-(4-hydroxy-benzoylamino)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | Biphenyl-3-sulfonic acid 2,4-dichloro-benzoylamide | Drug Info |
| HDAC1 --- HD6 | 2-(3-Benzenesulfonylamino-phenyl)-2-oxoethyl ethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | tyrphostin AG-825 | Drug Info |
| EGFR3 --- HER2 | 4-(3-azidophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E,4E)-Hexadienoyl]-7-{2-[5-methyl-2-(5-methylhexyl)oxazol-4-yl]ethoxy}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-2-ylmethyl)aniline | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(3-phenylpropyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-imidazol-1-ylmethyl-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | SID124349968 | Drug Info |
| HDAC1 --- HDAC2 | 7-(4-(3-bromophenyl)thiazol-2-yl)-N-hydroxyheptanamide | Drug Info |
| EGFR3 --- VEGFR1 | 3-{4-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-propan-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-N-m-tolylbenzamide | Drug Info |
| HDAC1 --- HDAC2 | 7-(4-(2,6-dimethoxyphenyl)thiazol-2-yl)-N-hydroxyheptanamide | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | methyl 2-(2-methyl-4-(3-(2-propyl-4-(trifluoromethyl)phenoxy)propoxy)phenoxy)acetate | Drug Info |
| VEGFR2 --- VEGFR1 | (5-Ethanesulfonyl-2-methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine | Drug Info |
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