Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 4-{(E)-1-[4-(2-Diethylamino-ethoxy)-phenyl]-3-methyl-but-1-enyl}-phenol | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(methyl(4-methylpiperazin-1-yl)amino)thiazol-4-yl)benzamide | Drug Info |
| Erbeta --- ER | 3-(3-Bromo-4-hydroxy-phenyl)-2,5-dimethyl-2H-benzo[1,4]oxazin-7-ol | Drug Info |
| MEP --- Cathepsin B | N-{(S)-1-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butyl}-benzamide | Drug Info |
| Erbeta --- ER | 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-2-yl)chroman-4-one | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Erbeta --- ER | 5-hydroxynaphthalen-1-yl 4-methoxybenzoate | Drug Info |
| Met --- VEGFR | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-N-methylthieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-7-(3-(2-chloro-4-isobutylphenoxy)propoxy)-2-methylchroman-2-carboxylic acid | Drug Info |
| Erbeta --- ER | CHEMBL187392 | Drug Info |
| Met --- VEGFR | methyl 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxylate | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(3-cyanophenyl)-3-(4-(trifluoromethyl)phenyl)propan-1-one | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-(4-piperazin-1-yl-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP1 --- MMP3 | [(S)-3-((R)-2-Hydroxycarbamoylmethyl-4-methyl-pentanoylamino)-2-oxo-azepan-1-yl]-acetic acid methyl ester | Drug Info |
| PR --- mRNA of AR | (R)-Ethyl 5-Cyano-6-methyl-2-propyl-4-quinolin-4-yl-1,4-dihydropyridine-3-carboxylate | Drug Info |
| Erbeta --- ER | 2-Bromo-N-[3-((R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-propyl]-acetamide | Drug Info |
| MMP1 --- MMP3 | 2-(2-Mercapto-acetyl)-nonanoic acid {(S)-2,2-dimethyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-propyl}-amide | Drug Info |
| PR --- mRNA of AR | (4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-phenyl)-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-(3-piperidin-1-yl-propyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP1 --- MMP3 | (R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-5-(3-phenyl-propionylamino)-pentanoic acid | Drug Info |
| PR --- mRNA of AR | 3'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitrile | Drug Info |
| Erbeta --- ER | 2,3-bis(4-hydroxyphenyl)pentanenitrile | Drug Info |
| MMP1 --- MMP9 | 11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 8-[(5-amino-1-methylcarbamoyl-pentyl)-amide] 12-hydroxyamide | Drug Info |
| PR --- mRNA of AR | (Z)-5-(2'-(3'-(1''-hydroxy-2'',2'',2''-trifluoroethyl)thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(3,3-Dimethyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP1 | tert-butyl 4-(4-(but-2-ynyloxy)phenylsulfonyl)-5-(hydroxycarbamoyl)-1,4-diazepane-1-carboxylate | Drug Info |
| PR --- mRNA of AR | Acetic acid 5-bromo-4-methoxy-2-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-phenyl ester | Drug Info |
| Erbeta --- ER | 6-(4-(ethylsulfonyl)phenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol | Drug Info |
| MMP13 --- MMP1 | SID137275936 | Drug Info |
| PR --- mRNA of AR | 9-bromo-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(4-Hydroxy-phenyl)-8-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethyl-6-(methylsulfonamidomethyl)thiomorpholine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | 1-methyl-5-(2-oxo-5-propyl-5-(thiophen-2-yl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-7-yl)-1H-pyrrole-2-carbonitrile | Drug Info |
| Erbeta --- ER | 6-chloro-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MMP13 --- MMP1 | 4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1-propionyl-1,4-diazepane-5-carboxamide | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(1-methyl-2-oxo-pyrrolidin-3-yl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | SID14725275 | Drug Info |
| MMP13 --- MMP1 | (S)-4-(4-(4-aminobut-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-5,6,9a,11a-tetramethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 2,3-Bis-(4-hydroxy-phenyl)-acrylonitrile | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-(4-m-tolyloxy-phenoxy)-piperidine-2,4,6-trione | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (4-methoxy-phenyl)-amide | Drug Info |
| Erbeta --- ER | 1-{2-[4-((3S,4R)-7-Methoxy-3-phenyl-isothiochroman-4-yl)-phenoxy]-ethyl}-pyrrolidine | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-2-{[4-(4-tert-butyl-phenoxy)-benzenesulfonyl]-methyl-amino}-N-hydroxy-3-methyl-benzamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-methoxy-phenyl ester | Drug Info |
| Erbeta --- ER | 2-(3,5-Difluoro-4-hydroxy-phenyl)-4-ethynyl-quinolin-6-ol | Drug Info |
| MMP2 --- HER2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (4-chloro-phenyl)-cyclopentyl-amide | Drug Info |
| Erbeta --- ER | SID3716652 | Drug Info |
| MMP2 --- MMP1 | (R)-N*1*-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-N*4*-pyridin-2-yl-succinamide | Drug Info |
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