Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | rac-3-(3-hydroxyphenyl)-2-methyl-6-(piperidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Erbeta --- ER | 2-p-Tolyl-benzo[b]thiophen-6-ol | Drug Info |
| MMP2 --- MMP1 | (7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-oxo-2-oxa-10-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-7,11-dicarboxylic acid 7-hydroxyamide 11-methylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-Phenyl-3-methyl-6-(morphilin-4-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Erbeta --- Mcl1 | SID85285613 | Drug Info |
| MMP2 --- MMP13 | 2-Biphenyl-4-yl-1,1-dioxo-1lambda*6*-isothiazolidine-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-2-methyl-6-morpholino-3-phenyl-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)-2-naphthamide | Drug Info |
| MMP2 --- MMP13 | 4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxy-1-(1-morpholinopropan-2-ylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-(3-fluorobenzyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-1-(4-{2-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-3-mercapto-propan-1-one | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylbenzo[b]thiophene-5-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzo[d][1,3]dioxole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-carbamoyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Bromo-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-[4-[3-(4-acetyl-piperazin-1-yl)-propyl]-1-(2-fluoro-5-trifluoromethyl-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone | Drug Info |
| Ftase --- FPTase | (S)-1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-2-carboxylic acid (3-imidazol-1-yl-propyl)-amide | Drug Info |
| MMP2 --- MMP13 | 4-(4-(4-(2-ethoxyphenyl)piperidin-1-yl)phenylsulfonyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | S-[cyclohexyl(diphenyl)methyl]-L-cysteine | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Bis-(4-nitro-benzyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-(dimethylamino)-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | [(S)-2-((S)-2-Cyclohexyl-1-phenethylcarbamoyl-ethylcarbamoyl)-5-phenyl-pentyl]-phosphonic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide | Drug Info |
| Ftase --- FPTase | 6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydroxy-prop-1-ynyl}-3''-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (2R,3S)-2-Allyl-N*4*-((S)-1-benzyl-2-oxo-2-thiophen-2-yl-ethyl)-N*1*-hydroxy-3-isobutyl-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3-fluoro-4-methoxyphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester | Drug Info |
| MMP2 --- MMP3 | (3R,4R)-N-hydroxy-4-(4-((2-methyl-1H-indol-3-yl)methyl)benzamido)-tetrahydro-2H-pyran-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-tert-butylphenyl)diphenylmethylthio)propanoic acid | Drug Info |
| Ftase --- FPTase | 2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid | Drug Info |
| MMP2 --- MMP3 | (S)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-indan-1-ylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-2-isobutyl-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-{[3'-fluoro-4'-(trifluoromethyl)-1,1'-biphenyl-4-yl]methyl}sulfamide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-dihydro-naphtho[1,2-b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(3'-chloro-4'-fluoro-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| Ftase --- FPTase | (S)-2-[(2'-Methyl-5-pyridin-3-ylethynyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (S)-2-(benzylamino)-N-hydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-(tritylthio)propan-1-ol | Drug Info |
| Ftase --- FPTase | (S)-2-Amino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-3-(4-methoxy-benzylsulfanyl)-propan-1-one | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-(3-morpholinopropyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 3-trifluoromethoxy-benzyl ester | Drug Info |
| MMP2 --- MMP9 | (S)-2-((4-(4-bromobenzamido)phenylsulfonyl)methyl)-3-(1H-indol-3-yl)propanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)cyclopentanecarboxamide | Drug Info |
| Ftase --- FPTase | N-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-N-(5-cyano-3''-ethoxy-biphenyl-2-ylmethyl)-methanesulfonamide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(2-chloro-6-methylpyridine-4-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| FGFR --- VEGFR | N-(3-chlorophenyl)-6-(5-{[3-(dimethylamino)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
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