Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | 2-[1,1-Dioxo-7-(2-trifluoromethyl-phenyl)-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-carboxylic acid | Drug Info |
| Ftase --- FPTase | 2-(1-Acetyl-piperidin-4-yl)-1-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone | Drug Info |
| MMP2 --- MMP9 | 5-(4-butyryl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-thiazol-5-yl-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| MMP3 --- MMP8 | (R)-5-(4-Methoxy-benzenesulfonyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | (S)-N-(4-(2-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| Ftase --- FPTase | 5-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-phenoxy-benzonitrile | Drug Info |
| MMP3 --- MMP8 | [2-(5-Isoxazol-3-yl-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-methoxyphenyl)malonamide | Drug Info |
| Ftase --- FPTase | N-(3-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzyl)methanesulfonamide | Drug Info |
| MMP3 --- MMP8 | Oxo-[2-(4-[1,2,3]triazol-2-yl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid | Drug Info |
| VEGFR2 --- CSrc | N-(4-methyl-3-(1-(6-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(6-hydroxy-hex-1-ynyl)-benzonitrile | Drug Info |
| mTOR --- AKT | (4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-{6-[(1R,2R)-2-(4-fluorophenyl)cyclopentylamino]pyrazin-2-yl}-methanone | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-5-(cyclohexyloxy)-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 4-[3-(3-Amino-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| mTOR --- AKT | N-(6-(2-(2-Fluorophenylsulfonamido)pyrimidin-4-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
| VEGFR2 --- CSrc | 2-(4-(6-(6-(2-(2-chloro-6-methylphenylamino)-1H-benzo[d]imidazol-1-yl)pyrimidin-4-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol | Drug Info |
| Ftase --- FPTase | 3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)urea | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-cyclopropyl-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-ylsulfanyl)-ethanone | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1-(3-morpholinopropyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- EGFR3 | CHEMBL1277620 | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid ethylamide | Drug Info |
| mTOR --- PI3K gamma | 4-(2-(benzo[d][1,3]dioxol-5-yl)-9H-purin-6-yl)morpholine | Drug Info |
| VEGFR2 --- FGFR1 | 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}urea | Drug Info |
| Ftase --- FPTase | 1-(2,3-dihydrobenzo[b]furan-5-yl)-11-[2-(2-methoxyphenyl)acryloyl]-(1R,8R,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-carboxylic acid (RPR208287) | Drug Info |
| mTOR --- PI3K gamma | 4-{3-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]ureido}benzamide | Drug Info |
| VEGFR2 --- TEK | N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)benzamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| NET --- SERT | 8-(3-Chloro-propyl)-3-(4-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| VEGFR2 --- TEK | 3-(2-(3H-imidazo[4,5-b]pyridin-6-yl)ethynyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | [(S)-3-Butyl-4-(3H-imidazol-4-ylmethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| NET --- SERT | 3-(4-Chloro-phenyl)-2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-8-methyl-8-aza-bicyclo[3.2.1]octane | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-6-isopropylthieno[2,3-d]pyrimidin-5-yl)phenyl)-3-m-tolylurea | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-3-Methyl-2-(2-phenylsulfanyl-acetylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N-(2-methoxyethyl)acrylamide | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(hydroxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 2-(2-Biphenyl-4-yl-ethoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | (1E,4Z,6E)-5-Hydroxy-1,7-bis(3-methoxy-4-(octyloxy)phenyl)-hepta-1,4,6-trien-3-one | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 9-cyclopentyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-phenyl-methanol | Drug Info |
| NPKCdelta --- NPKCtheta | 5-[(1E)-4-(4-Methoxypiperidin-1-yl)but-1-en-1-yl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(pyridin-4-ylmethyl)-2-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)aniline | Drug Info |
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