Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (R)-2-(naphthalen-2-ylsulfonyl)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Chlorothieno[3',2':4,5]imidazo[1,2-a]pyridine-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Renin --- Cathepsin D | (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imidazol-4-yl)-2-[2-(naphthalen-1-yloxy)-acetylamino]-propionylamino}-2-isopropyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide | Drug Info |
| Erbeta --- ER | SID862559 | Drug Info |
| MMP1 --- MMP3 | 1N-(3-methoxyphenyl)-2-[1-[1-amino-(1R)-ethylcarboxamido]-3-phenyl-(1S)-propylcarboxamido]-4-methyl-(2S)-pentanamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,6-bis-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-[6-methyl(3-pentylsulfanylpropyl)aminohexyl]-(E)-1-butenyl]phenol | Drug Info |
| MMP1 --- MMP3 | (R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-4-phenylacetylamino-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-tert-butyl-phenyl)-cycloheptyl]-amide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| MMP1 --- MMP9 | (R)-4-(5,7-Dioxo-5,7-dihydro-[1,3]dioxolo[4,5-f]isoindol-6-yl)-2-[(S)-3-methyl-1-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-butylamino]-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-N-phenyl-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 5,7-dihydroxy-3-(3-fluoro-4-hydroxyphenyl)-4(3H)-quinazolinethione | Drug Info |
| MMP1 --- MMP9 | 12-Isobutyl-13-oxo-1,7diaza-cyclotridecane-2,11-dicarboxylic acid 11-hydroxyamide 2-methylamide | Drug Info |
| S5AR --- SRD5A2 | 4-{3-[2,2-Bis-(4-chloro-phenyl)-benzo[1,3]dioxole-5-carbonyl]-2-methyl-indol-1-yl}-butyric acid | Drug Info |
| Erbeta --- ER | [2-(4-Ethylsulfanylmethyl-phenyl)-6-hydroxy-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP13 --- MMP1 | (4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-(3-fluoro-phenyl)-butyl]-phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-3-(dihydroxyphophono)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid diisopropylamide | Drug Info |
| Erbeta --- ER | (+/-)-1,2-Bis-(4-hydroxy-phenyl)-propane | Drug Info |
| MMP13 --- MMP1 | (2R,3S)-N1-((S)-3-(4-guanidinophenyl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutyl-3-(3-phenylpropyl)succinamide | Drug Info |
| S5AR --- SRD5A2 | 17-tert-Butylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(1,1-Dioxo-1lambda*6*-thiomorpholin-4-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzenesulfonyl]-5-hydroxy-3,3-dimethyl-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-methoxy-phenyl)-amide | Drug Info |
| Erbeta --- ER | 1-methyl-5-vinyl-9,10-dihydrophenanthrene-2,7-diol | Drug Info |
| MMP13 --- MMP1 | 1-benzoyl-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-1,4-diazepane-5-carboxamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-5-methoxy-4-methyl-phenylamino)-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 4-Chloro-2-(4-hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| MMP13 --- MMP1 | (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(quinolin-4-ylmethoxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-4-iodo-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 7-ethyl-4-fluoro-3,8-dihydroxy-6H-benzo[c]chromen-6-one | Drug Info |
| MMP13 --- MMP14 | 5-amino-3-(2-ethoxyethyl)-3-[4-(4-methanesulfonylphenoxy)phenoxy]piperidine-2,4,6-trione | Drug Info |
| FGFR --- Src | 3-(2,6-Dichloro-phenyl)-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Erbeta --- ER | 7-(3-Fluoro-4-hydroxy-phenyl)-3-hydroxy-4-methyl-naphthalene-1-carbonitrile | Drug Info |
| MMP13 --- MMP9 | 2-(4-but-2-ynyloxyphenylsulfanyl)octanoic acid hydroxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | methyl 4-((3-aminopropyl)(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)carbamoyl)benzoate | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-isopropyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP2 --- MMP1 | N-[1-(Biphenyl-4-yloxymethyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-N-hydroxy-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 9-(Trifluoromethyl)-4,7-dihydro-1H-pyrido[2,3-c]carbazol-3(2H)-one | Drug Info |
| Erbeta --- Mcl1 | SID14742218 | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-(pyridin-2-yl)piperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-Furan-6-methyl-N-(4-trifluoromethylphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
| FGFR --- PDGFR | 3-Phenyl-3H-benzoimidazol-5-ol | Drug Info |
| MMP2 --- MMP13 | (R)-2-(6-ethyl-N-isopentylnaphthalene-2-sulfonamido)-N-hydroxy-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1,5-di-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxy]-3-oxapentane | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(naphthalen-2-yloxy)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | CHEMBL1940308 | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-methyl-N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-butyl-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-N-(4-fluorobenzyl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
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