Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-yl]-benzoyl-amino}-4-methylsulfanyl-butyric acid methyl ester; hydrochloride | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid | Drug Info |
| VEGFR2 --- TEK | 7-acetyl-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-2-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetylamino}-3-methyl-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyramide | Drug Info |
| MMP2 --- MMP3 | (R)-N1-((S)-1-(cyclohexylamino)-3,3-dimethyl-1-oxobutan-2-yl)-N4-hydroxy-2-(3-phenylpropyl)succinamide | Drug Info |
| VEGFR2 --- TEK | N-(2-methoxy-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)benzamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((S)-3,7-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| MMP2 --- MMP8 | (cyclobutylamino)carbonylphosphonic acid | Drug Info |
| VEGFR2 --- VEGFR1 | (4-Chloro-phenyl)-[4-(2-methyl-pyridin-4-ylmethyl)-phthalazin-1-yl]-amine | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| MMP2 --- MMP9 | N-ethyl-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-4-phenoxybenzenesulfonamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | N-(4H-Benzo[1,3]dioxin-6-yl)-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP9 | 2,10-Dioxo-11-(3'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-oxo-2-piperazin-1-yl-ethyl)-amide] | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-chloro-3-(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| Ftase --- FPTase | (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-2-(4-Benzo[1,3]dioxol-5-yl-benzyl)-N*4*-hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-succinamide | Drug Info |
| VEGFR2 --- VEGFR1 | 4-[2-(5-Ethanesulfonyl-2-methoxy-phenylamino)-oxazol-5-yl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-[2-(4-chloro-phenyl)-acetyl]-piperazine-2-carboxylic acid methylamide | Drug Info |
| MMP2 --- MMP9 | (S)-3-(N-(4-(4-chlorophenoxy)phenyl)acetamido)-N,2-dihydroxypropanamide | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 6-[(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-piperazin-1-yl-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy)phenyl)-1H-imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,6-tetrahydro-pyridine-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | 2-(4'-cyano-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Bis-trifluoromethyl-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-isoindole-1,3-dione | Drug Info |
| MMP2 --- MMP9 | (S)-2-(cyclopentylamino)-N-hydroxy-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-methoxyphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | (R)-2-[(R)-2-((S)-2-Benzyl-3-phosphono-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester | Drug Info |
| MMP2 --- MMP9 | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(3-iodo-benzoyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-N-(3-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[4-(4-ethyl-phenylethynyl)-phenylsulfanyl]-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3-chloro-4-(trifluoromethyl)phenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | 1-[4-((S)-3-Bromo-8-chloro-10-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP3 --- MMP8 | [3-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid 4-methoxy-phenyl ester | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-quinolin-8-yl-benzonitrile | Drug Info |
| MMP3 --- MMP8 | {2-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophene-2-sulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 6-(((6-cyano-2'-(trifluoromethyl)biphenyl-3-yl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-2-((tetrahydrofuran-2-yl)methylamino)nicotinonitrile | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Fluoro-biphenyl-4-sulfonyl)-7-nitro-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(4-Cyano-3-naphthalen-1-yl-benzyl)-3H-imidazol-4-yl]-acetyl}-5-methoxy-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| MMP9 --- MMP8 | N-[(S)-2-Benzyloxy-1-((S)-1-phenyl-ethylcarbamoyl)-propyl]-N'-hydroxy-oxalamide | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-(2,3-dimethoxyphenoxy)benzonitrile | Drug Info |
| mTOR --- AKT | trans-2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-4-methyl-6-(6-methylpyridin-3-yl)pteridin-7(8H)-one | Drug Info |
| Ftase --- FPTase | [1-(3-Methyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
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