Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JNK1 --- JNK3 | 8-(6-methylpyridin-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | 2-Hydroxy-5-(5-hydroxy-2-naphthyl)benzonitrile | Drug Info |
| JNK1 --- JNK3 | N-(2-(1,3,4-oxadiazol-2-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-5-(3-(4-(4-phenoxy-2-propylphenoxy)butoxy)phenyl)thiazolidine-2,4-dione | Drug Info |
| Erbeta --- ER | 2-Benzyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| JNK1 --- JNK3 | 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-6-methylindolin-2-one | Drug Info |
| PR --- mRNA of AR | (Z)-5-(2'-(3'-((E)-1''-hydroxyiminoethyl)thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno-[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 9a-ethyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| MEP --- Cathepsin B | {1-[2-Oxo-1-phenethyl-3-(3-phenyl-propylsulfanyl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid pyridin-3-ylmethyl ester | Drug Info |
| PR --- mRNA of AR | 4-{4-[3-(4-{[Benzyl-(3-methanesulfonylamino-2-methyl-phenyl)-amino]-methyl}-phenoxy)-phenoxy]-butyrylamino}-butyric acid | Drug Info |
| Erbeta --- ER | 4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MEP --- Cathepsin B | 9-(3-hydroxy-propyl)-6-(4-methyl-benzylamino)-9H-purine-2-carbonitrile | Drug Info |
| PR --- mRNA of AR | 6,8,8,10-Tetramethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | 2-(3-fluoro-4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| MEP --- Cathepsin B | ethyl 3-((S)-3-((S)-2-(benzyloxycarbonyl)-3-phenylpropanamido)-2-oxo-4-phenylbutylthio)propanoate | Drug Info |
| PR --- mRNA of AR | cis-5,6-Diethyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Erbeta --- ER | CHEMBL1190385 | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-3-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)-1-oxopropan-2-yl)benzamide | Drug Info |
| PR --- mRNA of AR | 7-(diethylamino)-6-(thiophen-2-yl)-2H-chromen-2-one | Drug Info |
| Erbeta --- ER | (5R,6S)-6-phenyl-5-(4-((S)-2-(pyrrolidin-1-yl)propoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol | Drug Info |
| MEP --- Cathepsin B | N-[(3R)-1-cyano-3-pyrrolidinyl]-N'-phenylurea | Drug Info |
| PR --- mRNA of AR | 4-methyl-5-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrile | Drug Info |
| Erbeta --- ER | [4-(4-Benzoyl-piperazin-1-yl)-phenyl]-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-methanone | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| PR --- mRNA of AR | LONAPRISAN | Drug Info |
| Erbeta --- ER | 4-{(4S,5R)-2-Ethyl-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-4,5-dihydro-1H-imidazol-4-yl}-phenol | Drug Info |
| Met --- VEGFR | N,N-diethyl-7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| PR --- mRNA of AR | 7,7,8,8-Tetramethyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxy-3,5-dimethylphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| Met --- VEGFR | N-benzyl-7-(6,7-dimethoxyquinolin-4-yloxy)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide | Drug Info |
| Renin --- Cathepsin D | N1-((2S,3S,5S)-5-((S)-1-(benzylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-1-(benzyloxy)-3-hydroxy-6-methylheptan-2-yl)-5-(N-methylmethylsulfonamido)-N3-((R)-1-phenylethyl)isophthalamide | Drug Info |
| Erbeta --- ER | 4-{1-[4-(2-Diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-phenol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-[1-(1H-Benzoimidazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-N*4*-hydroxy-2-isobutyl-succinamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (4-tert-butyl-4'-chloro-biphenyl-3-yl)-amide | Drug Info |
| Erbeta --- ER | (R)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol | Drug Info |
| MMP1 --- MMP3 | (R)-2-((S)-4-(2-hydroxyphenyl)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxobutan-2-ylamino)propanoic acid | Drug Info |
| S5AR --- SRD5A2 | (8R,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | Arzoxifene | Drug Info |
| MMP1 --- MMP3 | [(S)-3-((2R,3R)-3-Hydroxycarbamoyl-2-isobutyl-hexanoylamino)-2-oxo-azepan-1-yl]-acetic acid methyl ester | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-benzyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 6-(3-Fluoro-4-hydroxy-phenyl)-8-prop-1-ynyl-naphthalen-2-ol | Drug Info |
| MMP1 --- MMP9 | Benzo[1,3]dioxole-5-carboxylic acid [(R)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-amide | Drug Info |
| S5AR --- SRD5A2 | 2-Cyano-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (2S,3S)-7-Hydroxy-2,3-bis-(4-hydroxy-phenyl)-chroman-4-one | Drug Info |
| MMP13 --- MMP1 | 4-(4-Benzyloxy-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 3-benzyl-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| MMP13 --- MMP1 | 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol | Drug Info |
| S5AR --- SRD5A2 | CHEMBL1201841 | Drug Info |
| Erbeta --- ER | 7-hydroxy-4-methyl-9a-phenyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
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