Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP3 | N-hydroxy-2-[4-(3'-methoxy-2-methyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide | Drug Info |
| PR --- mRNA of AR | 4-methyl-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-[2-(3-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP3 | N-[2-(4'-Cyano-biphenyl-4-yloxy)-ethyl]-N-hydroxy-acetamide | Drug Info |
| PR --- mRNA of AR | 5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-2-fluorobenzonitrile | Drug Info |
| Ftase --- FPTase | 4-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoylamino)-butyric acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-ylcarbamoyl)-propylcarbamoyl]-6-(4'-fluoro-biphenyl-4-yl)-hexanoic acid | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(3-bromophenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| Ftase --- FPTase | 3-alFPP | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2,3'-dimethyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid (1-cyclohexylmethyl-4-[1,3]dithian-2-yl-2,4-dihydroxy-butyl)-amide | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| MMP2 --- MMP9 | rac-N,2-dihydroxy-2-methyl-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| Renin --- Cathepsin D | 8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-4,8-dihydro-3H-imidazo[5,1-c][1,2,4]oxadiazin-6-amine | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP9 | 2-[7-(3,5-Dichloro-benzyloxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (3,5-di-tert-butyl-phenyl)-amide | Drug Info |
| Ftase --- FPTase | 1-((2R,3R)-3-Allyloxy-6-chloro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl)-1H-imidazole | Drug Info |
| MMP2 --- MMP9 | (S)-1-(biphenyl-4-ylsulfonyl)-N-hydroxy-5-oxopyrrolidine-2-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,10bR)-4,10b-Dimethyl-8-((E)-2-quinolin-3-yl-vinyl)-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(2-Methyl-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(2-(4-methoxyphenyl)ethynyl)phenyl)methan-8-ylsulfonamido)propanamide | Drug Info |
| S5AR --- SRD5A2 | (1S,10aR,12aS)-10a,12a-Dimethyl-8-oxo-1,2,3,3a,3b,4,5,6,8,9,10,10a,10b,11,12,12a-hexadecahydro-benzo[b]indeno[5,4-d]azepine-1-carboxylic acid diethylamide | Drug Info |
| Ftase --- FPTase | (2E,6E)-3-ethyl-7,11-dimethyldodeca-2,6,10-trienyl trihydrogen diphosphate | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-((R)-1-phenylethylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-methyl 9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylate | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-5,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | 2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)benzenesulfonamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(2-tert-butyl-5-(trifluoromethyl)phenyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-2-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Methyl-benzoylamino)-benzenesulfonylamino]-3-phenyl-propionic acid | Drug Info |
| S5AR --- SRD5A2 | 6-Benzyloxy-5-methoxy-1-methyl-1H-indole-2-carboxylic acid | Drug Info |
| Ftase --- FPTase | (+)4-{2-[4-(4-chloro-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethynyl)-benzenesulfonylamino]-propionic acid | Drug Info |
| ABL --- Src | 4-[2-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-hydroxy-propyl]-phenol | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propionylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP9 | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-(3'-methyl-biphenyl-4-ylmethyl)-succinamide | Drug Info |
| ABL --- Src | 4-(7-(2-chloro-6-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic 28 (FTI-2347) | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Ftase --- FPTase | Chaetomellic acid B | Drug Info |
| MMP3 --- MMP8 | 2-(5-Pyridin-2-yl-thiophen-2-ylmethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(7-methyl-9H-carbazol-3-yl)ethanone | Drug Info |
| Ftase --- FPTase | (S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylcarbamoyl)-butyric acid | Drug Info |
| MMP3 --- MMP8 | 2-(2-Pyridin-4-yl-ethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
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