Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 1,2-Bis-(4-hydroxy-phenyl)-prop-1-ene | Drug Info |
| MMP13 --- MMP1 | 4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetrahydro-thiopyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-7-(3,4-Dihydro-2H-quinoline-1-carbonyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | 4-Chloro-3-hydroxy-7-(4-hydroxy-phenyl)-naphthalene-1-carbonitrile | Drug Info |
| MMP13 --- MMP1 | [2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-phenyl-butyl]-[4-(2-trifluoromethyl-benzyl)-benzyl]-phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aR)-7-(1,5-Dimethyl-hexyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one | Drug Info |
| Erbeta --- ER | 2,4-diisobutylamino-6-isopentylpyrimidine | Drug Info |
| MMP13 --- MMP1 | 4-Benzyl-1-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]diazepane-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 7-chloro-4a-methyl-3,4,4a,9-tetrahydrophenanthren-2-ylphosphonous acid | Drug Info |
| Erbeta --- ER | 6-(4-Methanesulfonyl-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-naphthalen-2-ol; hydrochloride | Drug Info |
| MMP13 --- MMP1 | [2-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-phenyl-butyl]-[4-(2-ethyl-benzyl)-benzyl]-phosphinic acid | Drug Info |
| S5AR --- SRD5A2 | (8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-7-(4-(piperidin-1-yl)butoxy)-1H-indol-3-yl)acetamide | Drug Info |
| MMP13 --- MMP1 | (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-(1-isopropylcarbamoyl-piperidin-4-yl)-acetic Acid | Drug Info |
| S5AR --- SRD5A2 | 3-(17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-propionic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(2,2-Dimethyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-oxazol-5-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid p-tolyl ester | Drug Info |
| Erbeta --- ER | 4-[4-(1-Ethyl-2,3-diphenyl-propenyl)-phenoxymethyl]-morpholine | Drug Info |
| MMP13 --- MMP9 | N-Hydroxy-2-[methyl-(4-prop-2-ynylamino-benzenesulfonyl)-amino]-acetamide | Drug Info |
| ABL --- Src | (2,4-Dichloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-3-(4-Hydroxy-phenyl)-4-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-chroman-6-ol | Drug Info |
| MMP2 --- HER2 | (6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide | Drug Info |
| ABL --- Src | (4-tert-Butoxy-3,5-dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine | Drug Info |
| Erbeta --- Mcl1 | SID14726494 | Drug Info |
| MMP2 --- MMP13 | N-Hydroxy-2-{1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-cyclobutyl}-acetamide | Drug Info |
| FGFR --- Src | N-{6-(2,6-Dichloro-phenyl)-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrido[2,3-d]pyrimidin-7-yl}-3,3-dimethyl-butyramide | Drug Info |
| FGFR --- PDGFR | 3-Phenyl-3H-benzoimidazole-5-carboxylic acid methyl ester | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)-3,3-dimethylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(trifluoromethyl)-9H-carbazole | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-methyl-2-(N-(3-phenylpropyl)naphthalene-2-sulfonamido)butanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N,N-diethyl-2-(thiophene-2-carboxamido)-5,7-dihydro-4H-thieno[2,3-c]thiopyran-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid pyridin-3-ylamide | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-chloro-4-methoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-(2-methoxy-ethyl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-1-isobutyryl-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-Chloro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3-Bromo-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4-(5-(4-cyanobenzofuran-2-carboxamido)pyridin-2-yl)phenylsulfonamido)-3-methylbutanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| Ftase --- FPTase | 5-cyano-2-(((4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-N-phenylbenzamide | Drug Info |
| MMP2 --- MMP13 | 1-(4-(4-(hydroxycarbamoyl)tetrahydro-2H-pyran-4-ylsulfonyl)phenyl)-N-methyl-N-(prop-2-ynyl)piperidine-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 5-fluoro-2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-6-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(1-oxy-pyridin-4-ylmethyl)-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4'-methylsulfanyl-biphenyl-4-yl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclopropyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| MMP2 --- MMP3 | (R)-6-(4-chloro-phenyl)-3-{(S)-2-cyclohexyl-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-hexanoic acid | Drug Info |
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