Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Src --- VEGFR | CHEMBL383593 | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(3-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[4-(Adamantane-1-carbonyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| NPKCdelta --- NPKCtheta | (2S,5S)-8-Decyl-5-hydroxymethyl-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-benzo[e][1,4]oxazocin-3-one | Drug Info |
| Ftase --- FPTase | N-Cyclobutyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-3-ylmethyl-acetamide | Drug Info |
| VEGFR2 --- AuroraA | 6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(4-((2-methoxyethylamino)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| VEGFR2 --- CD135 | N-(3-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)phenyl)-4-morpholino-3-(trifluoromethyl)benzamide | Drug Info |
| CAII --- CAI | ([(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-{2-[(2-{[(2-bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-carboxymethyl-amino}-ethyl)-carboxymethyl-amino]-ethyl}-amino)-acetic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(2-cyclohexylvinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| VEGFR2 --- CDK1 | N,N-diethyl-2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxamide | Drug Info |
| EGFR3 --- HER2 | SID124349917 | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(4-(morpholinomethyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| H3 --- SERT | 3-(8-(3,4-dichlorophenyl)-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)-N,N-diethylpropan-1-amine | Drug Info |
| VEGFR2 --- CDK2 | 2-Oxo-3-[1-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-yl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | Drug Info |
| EGFR3 --- HER2 | N-(4-m-Tolylamino-pyrido[3,4-d]pyrimidin-6-yl)-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone | Drug Info |
| H3 --- SERT | (6S,10bR)-6-(4-(1H-pyrazol-1-yl)phenyl)-9-(3-morpholinopropoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| VEGFR2 --- Ckit | 1-methyl-3-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-1-m-tolylurea | Drug Info |
| EGFR3 --- HER2 | 4-(1H-indazol-5-ylamino)-6-aminopyrimidine-5-carbaldehyde O-methyl oxime | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| H3 --- SERT | 7-(3-(azetidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| VEGFR2 --- Cmet | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(2-(trifluoromethyl)phenyl)malonamide | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Phenoxy-phenylamino)-quinazolin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| H3 --- SERT | 7-(3-morpholinopropoxy)-4-phenyl-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-methoxyquinolin-6-yl)-4-(diethylamino)but-2-enamide | Drug Info |
| PKCA --- NPKC delta | ENZASTAURIN | Drug Info |
| HDAC1 --- Beta PDGFR | N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)terephthalamide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-(4-(dimethylamino)butylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| EGFR3 --- HER2 | (S)-N,N-dimethyl-2-(4-(1-(pyridin-2-ylmethyl)-1H-indazol-5-ylamino)quinazolin-5-yloxy)propanamide | Drug Info |
| PKCA --- NPKC delta | 4-[2-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-6-hydroxy-benzoyl]-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| HDAC1 --- HD6 | 2-[5-(3,5-Dimethyl-benzylcarbamoyl)-thiophen-2-yl]-2-oxoethylEthyl Trithiocarbonate | Drug Info |
| VEGFR2 --- CSrc | N-(2-chloro-5-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(4-((2-(methylsulfonyl)ethylamino)methyl)styryl)pyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 3-(4-hydroxy-phenyl)-1-methyl-propyl ester | Drug Info |
| HDAC1 --- HD6 | 2-(3-Acetylamino-phenyl)-2-oxoethyl Ethyl Trithiocarbonate | Drug Info |
| VEGFR2 --- CSrc | 2-((4-((2-(dimethylamino)ethyl)oxy)-phenyl)amino)-6-(2,6-dimethylphenyl)-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| EGFR3 --- HER2 | 1-{(E)-3-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-ylcarbamoyl]-allyl}-aziridine-2-carboxylic acid methyl ester | Drug Info |
| PKCA --- NPKC delta | 1-(3-Hydroxypropylamino-3-(2-methylaminopyridin-4-yl)[2,6]-naphthyridine | Drug Info |
| HDAC1 --- HD6 | 2-(5-(5-Amino-pyrid-2-yl)-thieno-2-yl)-2-oxoethyl Ethyl Trithiocarbonate | Drug Info |
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-4-(trifluoromethyl)benzamide | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(3,4,5-trifluorophenoxyacetamido)phenoxy]pyrimidine | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(2-isopropylphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-4-chlorobenzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(2-thienylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide | Drug Info |
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