Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((5-(4-isopropylphenyl)-1-methyl-1H-pyrazole-3-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-3,4-diazaindole-2-yl)carbamate | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-(5-hydroxypent-3-en-1-ynyl)picolinamide | Drug Info |
| Erbeta --- ER | (5,6-dihydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone | Drug Info |
| PPAR gamma --- PPAR delta | 3-{4-[3-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propoxy]-phenyl}-propionic acid | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(thiazol-2-yl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | 1-[6-Hydroxy-2-(4-hydroxy-phenyl)-quinolin-4-yl]-ethanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(1-(3-methoxybenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| VEGFR2 --- TEK | N-(3-(4-amino-5-(biphenyl-4-yl)furo[2,3-d]pyrimidin-6-yl)phenyl)methanesulfonamide | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-(trifluoromethoxy)phenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| Erbeta --- ER | SID17385432 | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-{[(5-biphenyl-4-yl-1-methyl-1H-pyrazole-3-carbonyl)-amino]-methyl}-2-methyl-phenoxy)-2-methyl-propionic acid | Drug Info |
| VEGFR2 --- TEK | 3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-[4-(methylsulfanyl)phenyl]urea | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylmethoxy)picolinamide | Drug Info |
| Erbeta --- ER | 3'-(methylamino)-1,1':2',1''-terphenyl-4'-carbaldehyde oxime | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(2-methyl-4-(3-(2-phenoxy-4-(trifluoromethoxy)phenoxy)butoxy)phenyl)propanoic acid | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-[(tert-butoxy)imino]ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | Geldanamycin | Drug Info |
| VEGFR2 --- VEGFR1 | [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-chloro-2-fluoro-phenyl)-amine | Drug Info |
| JNK1 --- JNK3 | N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinoxalin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(4-Chloro-phenoxy)-4-pyridin-4-ylmethyl-phthalazine | Drug Info |
| JNK1 --- JNK3 | 4-(9-cyclopentyl-8-(2-fluorophenylamino)-9H-purin-2-ylamino)cyclohexanol | Drug Info |
| Erbeta --- ER | 4-(2-(2-chlorophenyl)-1H-benzo[d]imidazol-1-yl)phenol | Drug Info |
| VEGFR2 --- VEGFR1 | Biphenyl-4-sulfonic acid 2,4-dichloro-benzoylamide | Drug Info |
| JNK1 --- JNK3 | 5-fluoro-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| JNK1 --- JNK3 | methyl 4-methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | 10-ethyl-3,8-dihydroxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| VEGFR2 --- VEGFR1 | 5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-N-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-amine | Drug Info |
| JNK3 --- MAPK | (S)-3-(4-Fluoro-phenyl)-N*1*-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)-propane-1,2-diamine | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[4-(2-Dimethylamino-ethoxy)-phenyl]-3-(3-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | Dimethyl-{3-[4-(3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidin-6-yl)-phenoxy]-propyl}-amine | Drug Info |
| MEP --- Cathepsin B | Allicin | Drug Info |
| Erbeta --- ER | 4-(4-hydroxyphenyl)benzo[b]thiophene-7-carbaldehyde oxime | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-3-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)-1-oxopropan-2-yl)benzamide | Drug Info |
| Erbeta --- ER | 6-hydroxy-3-{4-[2-(1-piperidinyl) ethoxy]phenoxy}-2-phenylbenzo[b] thiophene | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-Bromo-2-chloro-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| MEP --- Cathepsin B | [1-(1-Benzyl-3-tert-butylsulfanyl-2-oxo-propylcarbamoyl)-3-methyl-butyl]-carbamic acid pyridin-4-ylmethyl ester | Drug Info |
| Erbeta --- ER | (2S,3R)-2-[3-Bromo-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(3,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-naphthalen-1-yl-thioureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| Erbeta --- ER | 3-hydroxy-8-methoxy-4,7-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| VEGFR2 --- VEGFR1 | 3-methyl-5-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)isoxazole-4-carboxamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
| Erbeta --- ER | (2R,3S)-8-Chloro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | [5-(3-Chloro-phenyl)-oxazol-2-yl]-(5-ethanesulfonyl-2-methoxy-phenyl)-amine | Drug Info |
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