Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(propan-2-yl)-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']terphenyl-3-carboxylic acid 22 (FTI-2195) | Drug Info |
| NPKCdelta --- NPKCtheta | Octanoic acid (E)-(1S,5S,9S,11S,15R,19R,24S)-11-tert-butyl-1,15-dihydroxy-19-((R)-1-hydroxy-ethyl)-23-methoxycarbonylmethylene-2,2-dimethyl-17-oxo-6,12,18,25,26-pentaoxa-tricyclo[19.3.1.1*5,9*]hexacos-3-en-24-yl ester | Drug Info |
| VEGFR2 --- TEK | N-(4-phenoxyphenyl)-3-(3-(4-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-yl)pyridin-2-ylamino)benzamide | Drug Info |
| Ftase --- FPTase | 4-(3,3-dimethylbutyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[(3S)-3-Aminopyrrolidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(1H-pyrrol-1-yl)benzamide | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-4-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(4-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2-fluoro-4-methylphenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide | Drug Info |
| Ftase --- FPTase | 5-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-5-oxo-pentanoic acid | Drug Info |
| CAII --- CAI | 4-(Heptadecafluorooctane-1-sulfonylamino)-3-iodo-benzenesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(3-((dimethylamino)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | (1H-indazol-3-yl)(2-(quinolin-6-ylmethylamino)phenyl)methanone | Drug Info |
| H3 --- SERT | 2-methyl-4-phenyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(1-(3-fluorophenylsulfonyl)-1H-indazol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | GW631581B | Drug Info |
| H3 --- SERT | N-(4-(4-(3,4-dichlorophenoxy)-3-((methylamino)methyl)phenyl)but-3-ynyl)-N-methylcyclopropanamine | Drug Info |
| EGFR3 --- HER2 | N-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-2-dimethylaminomethyl-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645108 | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dimethoxyphenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-(3,4-dichlorophenyl)-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Chloro-4-fluoro-phenylamino)-quinazolin-6-yl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | (R)-2-(3-benzylmorpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzonitrile | Drug Info |
| EGFR3 --- HER2 | 4-(3-bromophenylamino)-6,7-dihydroxyquinoline-3-carbonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-phenyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-4-(2-(isoxazol-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| H3 --- SERT | N-ethyl-3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-methylpyrimidin-5-yl)-2-fluoro-N-(2-(pyrrolidin-1-yl)ethyl)acrylamide | Drug Info |
| PKCA --- NPKC delta | 2-{2,6-Dihydroxy-4-[(3R,4R)-2-(4-hydroxy-benzoylamino)-cyclopentyloxymethyl]-benzoyl}-3-hydroxy-benzoic acid | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-4-ylmethyl)aniline | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(2-(4-methoxyphenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | N-(4-(o-tolylamino)quinazolin-6-yl)acrylamide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-1-(toluene-4-sulfonyl)-azepan-4-yl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-4-(3-thiophen-3-yl-pyrazolo[1,5-a]pyrimidin-6-yl)-1H-pyridin-2-one | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(6-fluoroquinolin-4-yloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-methanesulfonyl-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 1-(3-Piperidin-1-yl-propyl)-3-(5-thiophen-3-yl-pyridin-3-yl)-1H-indole | Drug Info |
| HDAC1 --- HD6 | N1-hydroxy-N8-(4-((2R,4S,6R)-4-phenyl-6-((pyridin-4-ylthio)methyl)-1,3-dioxan-2-yl)phenyl)octanediamide | Drug Info |
| EGFR3 --- HER2 | CHEMBL258282 | Drug Info |
| PKCA --- NPKCtheta | 3-(5-(4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | 3-Chloro-N-(2,4-dichloro-benzoyl)-4-fluoro-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | N-hydroxy-3-(3-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | Drug Info |
| EGFR3 --- HER2 | SID85267487 | Drug Info |
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