Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| H3 --- SERT | N-methyl(5-(4-morpholinobut-1-ynyl)-2-phenoxyphenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | 5-((4-aminopiperidin-1-yl)methyl)-N-(3-chloro-4-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-morpholino-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PR --- mRNA of AR | 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-ol | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 1-(5-Chloro-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylthiourea | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957840 | Drug Info |
| PR --- mRNA of AR | 7,9-Difluoro-2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl ethyl carbonate | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(3-aminopropyl)-3-methyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| Renin --- Cathepsin D | (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-methoxybut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one | Drug Info |
| HD6 --- HDAC4 | 6-((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl)-N-hydroxyhexanamide | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dibromo-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| PKCA --- NPKC delta | 18-(1,4-oxazinan-4-ylmethyl)-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione | Drug Info |
| Renin --- Cathepsin D | (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(3-fluoropropoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one | Drug Info |
| HDAC1 --- HD6 | 3-(3-(4,5-dimethyl-1-(2-morpholinoethyl)-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | (2-Benzyl-1H-benzoimidazol-5-yl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,5R)-2-((S)-4-hydroxy-benzoylamino)-4-hydroxymethyl-cyclopentyl ester | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (2,6-dimethyl-phenyl)-amide | Drug Info |
| HDAC1 --- HD6 | 2,2,2-trifluoro-1-(2-(indoline-1-carbonyl)thiazol-5-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | 4-(2-Methoxymethyl-pyrrolidin-1-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PKCA --- NPKC delta | Benzolactam-V8 | Drug Info |
| S5AR --- SRD5A2 | ((10R,13S,17S)-17-Diisopropylcarbamoyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)-phosphonic acid | Drug Info |
| HDAC1 --- HD6 | 3-(3-(4-benzyl-5-methyl-1-(2-morpholinoethyl)-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyanoquinolin-6-yl)-4-(2-(methoxymethyl)pyrrolidin-1-yl)but-2-ynamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(3-methoxyphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-5,9a,11a-trimethyl-1-(3-methylbutanoyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| HDAC1 --- HD6 | (S)-3-(4-furan-3-yl-phenyl)-2-(7-hydroxycarbamoyl-heptanoylamino)-propionic acid methyl ester | Drug Info |
| EGFR3 --- HER2 | 4-(3-acetylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-chloro-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| S5AR --- SRD5A2 | (17-Diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)-acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-2-(8-hydroxycarbamoyl-octanoylamino)-3-(4-naphthalen-2-yl-phenyl)-propionic acid methyl ester | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid 2-(piperazin-1-yl)ethyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-((3-(4-isobutylphenyl)-1-methyl-1H-pyrazole-5-carboxamido)methyl)-2-methylphenoxy)-2-methylpropanoic acid | Drug Info |
| S5AR --- SRD5A2 | 4-Bromo-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| HDAC1 --- HDAC2 | 1H-Indole-7-carboxylic acid (5-hydroxycarbamoyl-pentyl)-amide | Drug Info |
| ER --- PR | 17alpha-Ethynyl-17-hydroxy-18-ethyl-4-estren-3-one | Drug Info |
| PPAR gamma --- PPAR delta | (R)-3-(1-((5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)-1H-indol-5-yl)-2-propoxypropanoic acid | Drug Info |
| S5AR --- SRD5A2 | (4aR,10bR)-4,10b-Dimethyl-8-((E)-styryl)-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| HDAC1 --- HDAC2 | 2-oxo-nonanedioic acid 9-biphenyl-3-ylamide 1-methylamide | Drug Info |
| Erbeta --- ER | 6-(3,4-difluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(2-(benzo[d]oxazol-2-yl(3-phenoxypropyl)amino)ethyl)phenoxy)propanoic acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6-Bromo-5,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid adamantan-1-ylamide | Drug Info |
| HDAC1 --- HDAC2 | 4-acetamido-N-(2-amino-5-(thiophen-2-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | methyl 2,3-bis(4-hydroxyphenyl)propanoate | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(4-(2-chloro-4-(4-fluorophenoxy)phenoxy)butoxy)phenoxy)-2-methylpropanoic acid | Drug Info |
| ABL --- Src | (2,4-Dichloro-5-methoxy-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-amine | Drug Info |
| HDAC1 --- HDAC2 | 3-[4-(Biphenyl-4-yloxy)-butylsulfanyl]-1,1,1-trifluoro-propan-2-one | Drug Info |
| Erbeta --- ER | 4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3H-inden-1-yl]-benzamide | Drug Info |
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